Embryological and clinical implications of the association between anorectal malformations and spinal dysraphisms

Giorgia Totonelli, Raffaella Messina, Francesco Morini, Giovanni Mosiello, Paolo Palma, Marianna Scuglia, Barbara D. Iacobelli, Pietro Bagolan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To describe the association of anorectal malformation (ARM) and spinal dysraphism (SD) in terms of impact on the management of SD and embryogenetic implications. Methods: Patients with SD associated with (A) or without (B) ARM were included. The two groups were further divided into operated on (A1/B1) or not (A2/B2) for SD. Groups A and B were compared for type of SD (embryogenetic classification) and prevalence of neurosurgery; Groups A1 vs. A2 for type of ARM (Wingspread classification); Groups A1 vs. B1 for age at neurosurgery, neurophysiology, and clinical symptoms. Main results: One hundred twenty-one patients with SD, 83 with and 38 without ARM were consecutively treated (1999–2015). Group A was associated only with SDs developing after primary neurulation, corresponding to the period of cloacal septation and organogenesis (p = 0.0007). Untethering surgery was significantly less frequent in Group A (p < 0.0001 and p = 0.04, respectively). Higher ARMs were not associated with increased risk for neurosurgery. No other significant differences were detected. Conclusions: In our series, ARMs were associated only with SD developing after primary neurulation, suggesting a single insult leading to both SD and the associated ARM. Neurosurgery is indicated less frequently in patients with ARM-associated SD, despite the similar preoperative clinical features.

Original languageEnglish
Pages (from-to)843-847
Number of pages5
JournalPediatric Surgery International
Volume33
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Spinal Dysraphism
Neurosurgery
Neurulation
varespladib methyl
Anorectal Malformations
Neurophysiology
Organogenesis

Keywords

  • Anorectal malformations
  • Embryogenesis
  • Neurulation
  • Spinal dysraphism
  • Spinal lipoma
  • Tethered cord

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Embryological and clinical implications of the association between anorectal malformations and spinal dysraphisms. / Totonelli, Giorgia; Messina, Raffaella; Morini, Francesco; Mosiello, Giovanni; Palma, Paolo; Scuglia, Marianna; Iacobelli, Barbara D.; Bagolan, Pietro.

In: Pediatric Surgery International, Vol. 33, No. 8, 01.08.2017, p. 843-847.

Research output: Contribution to journalArticle

@article{dae6294377334fab91edc6a113c159aa,
title = "Embryological and clinical implications of the association between anorectal malformations and spinal dysraphisms",
abstract = "Purpose: To describe the association of anorectal malformation (ARM) and spinal dysraphism (SD) in terms of impact on the management of SD and embryogenetic implications. Methods: Patients with SD associated with (A) or without (B) ARM were included. The two groups were further divided into operated on (A1/B1) or not (A2/B2) for SD. Groups A and B were compared for type of SD (embryogenetic classification) and prevalence of neurosurgery; Groups A1 vs. A2 for type of ARM (Wingspread classification); Groups A1 vs. B1 for age at neurosurgery, neurophysiology, and clinical symptoms. Main results: One hundred twenty-one patients with SD, 83 with and 38 without ARM were consecutively treated (1999–2015). Group A was associated only with SDs developing after primary neurulation, corresponding to the period of cloacal septation and organogenesis (p = 0.0007). Untethering surgery was significantly less frequent in Group A (p < 0.0001 and p = 0.04, respectively). Higher ARMs were not associated with increased risk for neurosurgery. No other significant differences were detected. Conclusions: In our series, ARMs were associated only with SD developing after primary neurulation, suggesting a single insult leading to both SD and the associated ARM. Neurosurgery is indicated less frequently in patients with ARM-associated SD, despite the similar preoperative clinical features.",
keywords = "Anorectal malformations, Embryogenesis, Neurulation, Spinal dysraphism, Spinal lipoma, Tethered cord",
author = "Giorgia Totonelli and Raffaella Messina and Francesco Morini and Giovanni Mosiello and Paolo Palma and Marianna Scuglia and Iacobelli, {Barbara D.} and Pietro Bagolan",
year = "2017",
month = "8",
day = "1",
doi = "10.1007/s00383-017-4104-5",
language = "English",
volume = "33",
pages = "843--847",
journal = "Pediatric Surgery International",
issn = "0179-0358",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Embryological and clinical implications of the association between anorectal malformations and spinal dysraphisms

AU - Totonelli, Giorgia

AU - Messina, Raffaella

AU - Morini, Francesco

AU - Mosiello, Giovanni

AU - Palma, Paolo

AU - Scuglia, Marianna

AU - Iacobelli, Barbara D.

AU - Bagolan, Pietro

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose: To describe the association of anorectal malformation (ARM) and spinal dysraphism (SD) in terms of impact on the management of SD and embryogenetic implications. Methods: Patients with SD associated with (A) or without (B) ARM were included. The two groups were further divided into operated on (A1/B1) or not (A2/B2) for SD. Groups A and B were compared for type of SD (embryogenetic classification) and prevalence of neurosurgery; Groups A1 vs. A2 for type of ARM (Wingspread classification); Groups A1 vs. B1 for age at neurosurgery, neurophysiology, and clinical symptoms. Main results: One hundred twenty-one patients with SD, 83 with and 38 without ARM were consecutively treated (1999–2015). Group A was associated only with SDs developing after primary neurulation, corresponding to the period of cloacal septation and organogenesis (p = 0.0007). Untethering surgery was significantly less frequent in Group A (p < 0.0001 and p = 0.04, respectively). Higher ARMs were not associated with increased risk for neurosurgery. No other significant differences were detected. Conclusions: In our series, ARMs were associated only with SD developing after primary neurulation, suggesting a single insult leading to both SD and the associated ARM. Neurosurgery is indicated less frequently in patients with ARM-associated SD, despite the similar preoperative clinical features.

AB - Purpose: To describe the association of anorectal malformation (ARM) and spinal dysraphism (SD) in terms of impact on the management of SD and embryogenetic implications. Methods: Patients with SD associated with (A) or without (B) ARM were included. The two groups were further divided into operated on (A1/B1) or not (A2/B2) for SD. Groups A and B were compared for type of SD (embryogenetic classification) and prevalence of neurosurgery; Groups A1 vs. A2 for type of ARM (Wingspread classification); Groups A1 vs. B1 for age at neurosurgery, neurophysiology, and clinical symptoms. Main results: One hundred twenty-one patients with SD, 83 with and 38 without ARM were consecutively treated (1999–2015). Group A was associated only with SDs developing after primary neurulation, corresponding to the period of cloacal septation and organogenesis (p = 0.0007). Untethering surgery was significantly less frequent in Group A (p < 0.0001 and p = 0.04, respectively). Higher ARMs were not associated with increased risk for neurosurgery. No other significant differences were detected. Conclusions: In our series, ARMs were associated only with SD developing after primary neurulation, suggesting a single insult leading to both SD and the associated ARM. Neurosurgery is indicated less frequently in patients with ARM-associated SD, despite the similar preoperative clinical features.

KW - Anorectal malformations

KW - Embryogenesis

KW - Neurulation

KW - Spinal dysraphism

KW - Spinal lipoma

KW - Tethered cord

UR - http://www.scopus.com/inward/record.url?scp=85020636103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020636103&partnerID=8YFLogxK

U2 - 10.1007/s00383-017-4104-5

DO - 10.1007/s00383-017-4104-5

M3 - Article

AN - SCOPUS:85020636103

VL - 33

SP - 843

EP - 847

JO - Pediatric Surgery International

JF - Pediatric Surgery International

SN - 0179-0358

IS - 8

ER -