Embryonal rhabdomyosarcoma of the uterine cervix in adults: A case report and literature review

Antonino Ditto, Fabio Martinelli, Marialuisa Carcangiu, Eugenio Solima, Karla Jeanette Amaya De Carrillo, Roberta Sanfilippo, Edward Haeusler, Francesco Raspagliesi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE: We report a case of cervical rhabdomyosarcoma in an adult and review of literature. MATERIALS AND METHODS: A 44-year-old, premenopausal, white woman, complained of vaginal bleeding for 2 months. The gynecological examination showed a cervical polyp protruding from the vagina. The polyp was partially removed by polypectomy. Pathological examination was diagnostic for embryonal rhabdomyosarcoma-botryoid type-of the cervix. Radical class II hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic lymphadenectomy were performed. Adjuvant multidrug chemotherapy (vincristine, doxorubicin, ifosfamide, and etoposide) plus external beam radiotherapy were administered. Forty-six months after diagnosis, the patient is disease free. RESULTS: Here, we report a new case and a literature review of a fairly rare cancer, rhabdomyosarcoma of the cervix in an adult. Pathological features and treatment with an aggressive multimodal approach (radical surgery followed by multidrug adjuvant chemotherapy and radiotherapy) are reported. Good treatment-tolerance and optimal results were achieved. CONCLUSIONS: Every effort should be done during both the diagnostic and therapeutic phase to offer these patients the best chance of survival. Further studies on best approach, chemotherapeutic protocols, and outcome in adults are warranted.

Original languageEnglish
JournalJournal of Lower Genital Tract Disease
Volume17
Issue number4
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Embryonal Rhabdomyosarcoma
Cervix Uteri
Rhabdomyosarcoma
Adjuvant Chemotherapy
Polyps
Gynecological Examination
Ifosfamide
Adjuvant Radiotherapy
Uterine Hemorrhage
Ovariectomy
Vincristine
Vagina
Etoposide
Lymph Node Excision
Hysterectomy
Uterine Cervical Neoplasms
Doxorubicin
Radiotherapy
Therapeutics
Survival

Keywords

  • adult
  • botryoid
  • cervical cancer
  • embryonal rhabdomyosarcoma
  • multimodal treatment

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Embryonal rhabdomyosarcoma of the uterine cervix in adults : A case report and literature review. / Ditto, Antonino; Martinelli, Fabio; Carcangiu, Marialuisa; Solima, Eugenio; De Carrillo, Karla Jeanette Amaya; Sanfilippo, Roberta; Haeusler, Edward; Raspagliesi, Francesco.

In: Journal of Lower Genital Tract Disease, Vol. 17, No. 4, 10.2013.

Research output: Contribution to journalArticle

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