Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article

M. Bizzarri, A. Cucina, P. M. Biava, S. Proietti, F. D'Anselmi, S. Dinicola, A. Pasqualato, E. Lisi

Research output: Contribution to journalArticle

Abstract

Cancer cells introduced into developing embryos can be committed to a complete reversion of their malignant phenotype. It is unlikely that such effects could be ascribed to only few molecular components interacting according to a simple linear-dynamics model, and they claim against the somatic mutation theory of cancer. Some 50 years ago, Needham and Waddington speculated that cancer represents an escape from morphogenetic field like those which guide embryonic development. Indeed, disruption of the morphogenetic field of a tissue can promote the onset as well as the progression of cancer. On the other hand, placing tumor cells into a "normal" morphogenetic field - like that of an embryonic tissue - one can reverse malignant phenotype, "reprogramming" tumor into normal cells. According to the theoretical framework provided by the thermodynamics of dissipative systems, morphogenetic fields could be considered as distinct attractors, to which cell behaviors are converging. Cancer-attractors are likely positioned somewhat close to embryonicattractors. Indeed, tumors share several morphological and ultra-structural features with embryonic cells. The recovering of an "embryonic-like" cell shape might enable the gene regulatory network to reactivate embryonic programs, and consequently to express antigenic and biochemical embryonic characters. This condition confers to cancer an unusual sensitivity to embryonic regulatory cues. Thus, it is not surprising that cancer cells exposed to specific embryonic morphogenetic fields undergoes significant modifications, eventually leading to a complete phenotypic reversion.

Original languageEnglish
Pages (from-to)243-253
Number of pages11
JournalCurrent Pharmaceutical Biotechnology
Volume12
Issue number2
Publication statusPublished - 2011

Fingerprint

Neoplasms
Phenotype
Cell Shape
Gene Regulatory Networks
Thermodynamics
Embryonic Development
Cues
Linear Models
Embryonic Structures
Mutation

Keywords

  • Cancer-attractors
  • Embryonic stem cells
  • Embryonic-attractors
  • Morphogenetic field
  • Phenotypic reversion

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Biotechnology

Cite this

Bizzarri, M., Cucina, A., Biava, P. M., Proietti, S., D'Anselmi, F., Dinicola, S., ... Lisi, E. (2011). Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article. Current Pharmaceutical Biotechnology, 12(2), 243-253.

Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article. / Bizzarri, M.; Cucina, A.; Biava, P. M.; Proietti, S.; D'Anselmi, F.; Dinicola, S.; Pasqualato, A.; Lisi, E.

In: Current Pharmaceutical Biotechnology, Vol. 12, No. 2, 2011, p. 243-253.

Research output: Contribution to journalArticle

Bizzarri, M, Cucina, A, Biava, PM, Proietti, S, D'Anselmi, F, Dinicola, S, Pasqualato, A & Lisi, E 2011, 'Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article', Current Pharmaceutical Biotechnology, vol. 12, no. 2, pp. 243-253.
Bizzarri M, Cucina A, Biava PM, Proietti S, D'Anselmi F, Dinicola S et al. Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article. Current Pharmaceutical Biotechnology. 2011;12(2):243-253.
Bizzarri, M. ; Cucina, A. ; Biava, P. M. ; Proietti, S. ; D'Anselmi, F. ; Dinicola, S. ; Pasqualato, A. ; Lisi, E. / Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article. In: Current Pharmaceutical Biotechnology. 2011 ; Vol. 12, No. 2. pp. 243-253.
@article{e6dcd866363240c0b5fe891d198a53d4,
title = "Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article",
abstract = "Cancer cells introduced into developing embryos can be committed to a complete reversion of their malignant phenotype. It is unlikely that such effects could be ascribed to only few molecular components interacting according to a simple linear-dynamics model, and they claim against the somatic mutation theory of cancer. Some 50 years ago, Needham and Waddington speculated that cancer represents an escape from morphogenetic field like those which guide embryonic development. Indeed, disruption of the morphogenetic field of a tissue can promote the onset as well as the progression of cancer. On the other hand, placing tumor cells into a {"}normal{"} morphogenetic field - like that of an embryonic tissue - one can reverse malignant phenotype, {"}reprogramming{"} tumor into normal cells. According to the theoretical framework provided by the thermodynamics of dissipative systems, morphogenetic fields could be considered as distinct attractors, to which cell behaviors are converging. Cancer-attractors are likely positioned somewhat close to embryonicattractors. Indeed, tumors share several morphological and ultra-structural features with embryonic cells. The recovering of an {"}embryonic-like{"} cell shape might enable the gene regulatory network to reactivate embryonic programs, and consequently to express antigenic and biochemical embryonic characters. This condition confers to cancer an unusual sensitivity to embryonic regulatory cues. Thus, it is not surprising that cancer cells exposed to specific embryonic morphogenetic fields undergoes significant modifications, eventually leading to a complete phenotypic reversion.",
keywords = "Cancer-attractors, Embryonic stem cells, Embryonic-attractors, Morphogenetic field, Phenotypic reversion",
author = "M. Bizzarri and A. Cucina and Biava, {P. M.} and S. Proietti and F. D'Anselmi and S. Dinicola and A. Pasqualato and E. Lisi",
year = "2011",
language = "English",
volume = "12",
pages = "243--253",
journal = "Current Pharmaceutical Biotechnology",
issn = "1389-2010",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Embryonic morphogenetic field induces phenotypic reversion in cancer cells. review article

AU - Bizzarri, M.

AU - Cucina, A.

AU - Biava, P. M.

AU - Proietti, S.

AU - D'Anselmi, F.

AU - Dinicola, S.

AU - Pasqualato, A.

AU - Lisi, E.

PY - 2011

Y1 - 2011

N2 - Cancer cells introduced into developing embryos can be committed to a complete reversion of their malignant phenotype. It is unlikely that such effects could be ascribed to only few molecular components interacting according to a simple linear-dynamics model, and they claim against the somatic mutation theory of cancer. Some 50 years ago, Needham and Waddington speculated that cancer represents an escape from morphogenetic field like those which guide embryonic development. Indeed, disruption of the morphogenetic field of a tissue can promote the onset as well as the progression of cancer. On the other hand, placing tumor cells into a "normal" morphogenetic field - like that of an embryonic tissue - one can reverse malignant phenotype, "reprogramming" tumor into normal cells. According to the theoretical framework provided by the thermodynamics of dissipative systems, morphogenetic fields could be considered as distinct attractors, to which cell behaviors are converging. Cancer-attractors are likely positioned somewhat close to embryonicattractors. Indeed, tumors share several morphological and ultra-structural features with embryonic cells. The recovering of an "embryonic-like" cell shape might enable the gene regulatory network to reactivate embryonic programs, and consequently to express antigenic and biochemical embryonic characters. This condition confers to cancer an unusual sensitivity to embryonic regulatory cues. Thus, it is not surprising that cancer cells exposed to specific embryonic morphogenetic fields undergoes significant modifications, eventually leading to a complete phenotypic reversion.

AB - Cancer cells introduced into developing embryos can be committed to a complete reversion of their malignant phenotype. It is unlikely that such effects could be ascribed to only few molecular components interacting according to a simple linear-dynamics model, and they claim against the somatic mutation theory of cancer. Some 50 years ago, Needham and Waddington speculated that cancer represents an escape from morphogenetic field like those which guide embryonic development. Indeed, disruption of the morphogenetic field of a tissue can promote the onset as well as the progression of cancer. On the other hand, placing tumor cells into a "normal" morphogenetic field - like that of an embryonic tissue - one can reverse malignant phenotype, "reprogramming" tumor into normal cells. According to the theoretical framework provided by the thermodynamics of dissipative systems, morphogenetic fields could be considered as distinct attractors, to which cell behaviors are converging. Cancer-attractors are likely positioned somewhat close to embryonicattractors. Indeed, tumors share several morphological and ultra-structural features with embryonic cells. The recovering of an "embryonic-like" cell shape might enable the gene regulatory network to reactivate embryonic programs, and consequently to express antigenic and biochemical embryonic characters. This condition confers to cancer an unusual sensitivity to embryonic regulatory cues. Thus, it is not surprising that cancer cells exposed to specific embryonic morphogenetic fields undergoes significant modifications, eventually leading to a complete phenotypic reversion.

KW - Cancer-attractors

KW - Embryonic stem cells

KW - Embryonic-attractors

KW - Morphogenetic field

KW - Phenotypic reversion

UR - http://www.scopus.com/inward/record.url?scp=79551630120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551630120&partnerID=8YFLogxK

M3 - Article

C2 - 21044001

AN - SCOPUS:79551630120

VL - 12

SP - 243

EP - 253

JO - Current Pharmaceutical Biotechnology

JF - Current Pharmaceutical Biotechnology

SN - 1389-2010

IS - 2

ER -