Abstract
BACKGROUND: Nearly every anesthetic agent has been used for craniotomy, yet the choice between intravenous or volatile agents has been considered an area of significant debate in neuroanesthesia. We designed a Randomized Clinical Trial to test the hypothesis that inhalation anesthesia (sevoflurane/ remifentanil-group S) reduces emergence time by 5 minutes compared with intravenous anesthesia (propofol/remifentanil-group P) in patients undergoing neurosurgery for supratentorial neoplasms. METHODS: Adult ASA I-III elective patients were randomly assigned to group S or P. The primary outcome was time to reach an Aldrete test score (AS) of more than equal to 9; secondary outcomes were times to eyes opening (TEO) and extubation (ET), adverse events, intraoperative hemodynamics, brain relaxation score (BRS), opioid consumption, and diuresis. RESULTS: No significant differences were found between S (n=149) and P (n=153) treatments in primary outcomes: median time to reach AS=9 was 5 minutes (25th to 75th percentile 5 to 10 minutes in both groups, P ≥ 0.05); and 15 minutes to reach AS=10 (P group 95% CI=10.3-19.7 min; S group 95% CI=11.4-18.5min, P ≥ 0.05) in both groups.TEO and ET expressed as median values (95% CI) were, respectively: 8 (6.8 to 9.2) minutes in group P versus 6 (4.6 to 7.4) in group S, P
| Original language | English |
|---|---|
| Pages (from-to) | 110-118 |
| Number of pages | 9 |
| Journal | Journal of Neurosurgical Anesthesiology |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2010 |
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Keywords
- Craniotomy
- Inhalation anesthesia
- Intravenous anesthesia
- Neurosurgery
- Neurosurgical anesthesia
- Propofol
- Sevoflurane
- Superiority clinical trial
- Supratentorial neoplasms
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
- Clinical Neurology
- Surgery
Cite this
Emergence times are similar with sevoflurane and total intravenous anesthesia : Results of a multicenter rct of patients scheduled for elective supratentorial craniotomy. / Lauta, Enrico; Abbinante, Crescenza; Gaudio, Alfredo Del; Aloj, Fulvio; Fanelli, Margherita; De Vivo, Paolo; Tommasino, Concezione; Fiore, Tommaso.
In: Journal of Neurosurgical Anesthesiology, Vol. 22, No. 2, 04.2010, p. 110-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emergence times are similar with sevoflurane and total intravenous anesthesia
T2 - Results of a multicenter rct of patients scheduled for elective supratentorial craniotomy
AU - Lauta, Enrico
AU - Abbinante, Crescenza
AU - Gaudio, Alfredo Del
AU - Aloj, Fulvio
AU - Fanelli, Margherita
AU - De Vivo, Paolo
AU - Tommasino, Concezione
AU - Fiore, Tommaso
PY - 2010/4
Y1 - 2010/4
N2 - BACKGROUND: Nearly every anesthetic agent has been used for craniotomy, yet the choice between intravenous or volatile agents has been considered an area of significant debate in neuroanesthesia. We designed a Randomized Clinical Trial to test the hypothesis that inhalation anesthesia (sevoflurane/ remifentanil-group S) reduces emergence time by 5 minutes compared with intravenous anesthesia (propofol/remifentanil-group P) in patients undergoing neurosurgery for supratentorial neoplasms. METHODS: Adult ASA I-III elective patients were randomly assigned to group S or P. The primary outcome was time to reach an Aldrete test score (AS) of more than equal to 9; secondary outcomes were times to eyes opening (TEO) and extubation (ET), adverse events, intraoperative hemodynamics, brain relaxation score (BRS), opioid consumption, and diuresis. RESULTS: No significant differences were found between S (n=149) and P (n=153) treatments in primary outcomes: median time to reach AS=9 was 5 minutes (25th to 75th percentile 5 to 10 minutes in both groups, P ≥ 0.05); and 15 minutes to reach AS=10 (P group 95% CI=10.3-19.7 min; S group 95% CI=11.4-18.5min, P ≥ 0.05) in both groups.TEO and ET expressed as median values (95% CI) were, respectively: 8 (6.8 to 9.2) minutes in group P versus 6 (4.6 to 7.4) in group S, P
AB - BACKGROUND: Nearly every anesthetic agent has been used for craniotomy, yet the choice between intravenous or volatile agents has been considered an area of significant debate in neuroanesthesia. We designed a Randomized Clinical Trial to test the hypothesis that inhalation anesthesia (sevoflurane/ remifentanil-group S) reduces emergence time by 5 minutes compared with intravenous anesthesia (propofol/remifentanil-group P) in patients undergoing neurosurgery for supratentorial neoplasms. METHODS: Adult ASA I-III elective patients were randomly assigned to group S or P. The primary outcome was time to reach an Aldrete test score (AS) of more than equal to 9; secondary outcomes were times to eyes opening (TEO) and extubation (ET), adverse events, intraoperative hemodynamics, brain relaxation score (BRS), opioid consumption, and diuresis. RESULTS: No significant differences were found between S (n=149) and P (n=153) treatments in primary outcomes: median time to reach AS=9 was 5 minutes (25th to 75th percentile 5 to 10 minutes in both groups, P ≥ 0.05); and 15 minutes to reach AS=10 (P group 95% CI=10.3-19.7 min; S group 95% CI=11.4-18.5min, P ≥ 0.05) in both groups.TEO and ET expressed as median values (95% CI) were, respectively: 8 (6.8 to 9.2) minutes in group P versus 6 (4.6 to 7.4) in group S, P
KW - Craniotomy
KW - Inhalation anesthesia
KW - Intravenous anesthesia
KW - Neurosurgery
KW - Neurosurgical anesthesia
KW - Propofol
KW - Sevoflurane
KW - Superiority clinical trial
KW - Supratentorial neoplasms
UR - http://www.scopus.com/inward/record.url?scp=77949986594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949986594&partnerID=8YFLogxK
U2 - 10.1097/ANA.0b013e3181c959da
DO - 10.1097/ANA.0b013e3181c959da
M3 - Article
C2 - 20308817
AN - SCOPUS:77949986594
VL - 22
SP - 110
EP - 118
JO - Journal of Neurosurgical Anesthesiology
JF - Journal of Neurosurgical Anesthesiology
SN - 0898-4921
IS - 2
ER -