Emergency heart retransplantation with a positive donor crossmatch

G. Ippoliti, L. Martinelli, G. Minzioni, C. Goggi, A. Graffigna, M. Rinaldi, C. Campana, E. Ascari, M. Vigano

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of one patient who underwent emergency retransplantation with a highly positive donor crossmatch. Standard immunosuppression was integrated by the addition of plasma exchange during extracorporeal circulation, polyclonal IgG, and cyclophosphamide for the first 30 days. After transplantation the clinical outcome was normal; immunosuppression induced a complete disappearance of the donor-specific antibody. In spite of the heavy immunosuppression, we did not observe any infectious complications. We suggest that a greater immunosuppression established soon after the transplant and adjusted on the basis of immunological monitoring may allow a heart transplant with a positive crossmatch.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalJournal of Heart Transplantation
Volume8
Issue number2
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Transplantation

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