Emerging drugs for the treatment of ulcerative colitis

Luca Pastorelli, Theresa T. Pizarro, Fabio Cominelli, Maurizio Vecchi

Research output: Contribution to journalArticle

Abstract

Background: Ulcerative colitis (UC) is a chronic, relapsing inflammatory disorder of the colon for which the etiology is currently unknown. At present, strategies to treat UC are primarily targeted to control inflammation during active phases of disease as well as maintain remission during quiescence. As such, several unmet needs in the treatment of UC still remain. In recent years, basic research has led to the recognition of several key factors in the pathogenesis of UC, translating into the development of several novel therapeutic agents. Objective: The aim of this study is to review emerging therapies that may advance the treatment and improve the overall care of UC patients. Methods: An extensive literature search on published manuscripts and meeting proceedings has been performed to provide a comprehensive review of future drug therapies to treat UC. Results/conclusion: The translational application of new discoveries in the basic understanding of UC pathogenesis is continuing and critical for the development of novel treatment strategies. Design of novel biologic therapies to treat UC has the challenge of addressing potential safety issues, while more traditional drugs should be further developed to facilitate patient compliance to treat this chronic, debilitating disease.

Original languageEnglish
Pages (from-to)505-521
Number of pages17
JournalExpert Opinion on Emerging Drugs
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Adhesion molecules
  • Biologic drugs
  • CD3
  • CTLA-4
  • IL-2 receptor
  • Inflammatory bowel disease
  • MMX
  • PPAR-γ
  • Probiotics
  • Therapy
  • TNF-α
  • Treatment
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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