Emerging Mechanisms in Initiating and Terminating Autophagy

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Abstract

Autophagy is a major degradative process activated in a rapid and transient manner to cope with stress conditions. Whether autophagy is beneficial or detrimental depends upon the rate of induction and the appropriateness of the duration. Alterations in both autophagy initiation and termination predispose the cell to death, and affect the execution of other inducible processes such as inflammation. In this review we discuss how stress signaling pathways dynamically control the activity of the autophagy machinery by mediating post-translational modifications and regulatory protein interactions. In particular, we highlight the emerging role of TRIM and CULLIN families of ubiquitin ligases which play opposite roles in the autophagy response by promoting or inhibiting, respectively, the activity of the autophagy initiation complex.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalTrends in Biochemical Sciences
DOIs
Publication statusE-pub ahead of print - Oct 17 2016

Keywords

  • AMBRA1
  • BECLIN-1
  • CULLIN
  • Exocyst
  • IRGM.
  • TRAF6
  • TRIM
  • ULK1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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