Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L

Roberta Di Pietro, Giorgio Zauli

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Tumor necrosis factor (TNF) is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF super-family and 21 different receptors have been identified. All ligands of the TNF super-family have been found to activate transcription factor NF-κB and c-Jun kinase. Members of this family have diverse biological effects, including induction of apoptosis, promotion of cell survival, and regulation of the immune system and hematopoiesis. The current review focuses on the biological effects of TNF-related apoptosis-inducing ligand (TRAIL), a TNF super-family member which, a few years ago, generated considerable enthusiasm for its anticancer activity, not accompanied by general toxicity in most normal tissues and organs.

Original languageEnglish
Pages (from-to)331-340
Number of pages10
JournalJournal of Cellular Physiology
Volume201
Issue number3
DOIs
Publication statusPublished - Dec 2004

Fingerprint

TNF-Related Apoptosis-Inducing Ligand
Cell death
Tumor Necrosis Factor-alpha
Ligands
Apoptosis
Immune system
Hematopoiesis
Toxicity
Tumors
Immune System
Cell Survival
Transcription Factors
Necrosis
Phosphotransferases
Cells
Tissue
Cytokines
Neoplasms

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L. / Di Pietro, Roberta; Zauli, Giorgio.

In: Journal of Cellular Physiology, Vol. 201, No. 3, 12.2004, p. 331-340.

Research output: Contribution to journalArticle

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