Emerging perspectives on laminopathies

Giovanna Lattanzi, Sara Benedetti, Maria Rosaria D’Apice, Lorenzo Maggi, Nicola Carboni, Emanuela Scarano, Luisa Politano

Research output: Contribution to journalArticlepeer-review

Abstract

Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

Original languageEnglish
Pages (from-to)25-35
Number of pages11
JournalCell Health and Cytoskeleton
Volume8
DOIs
Publication statusPublished - Apr 7 2016

Keywords

  • Emerin
  • Emery–Dreifuss muscular dystrophy
  • Hutchinson–Gilford progeria
  • Lamin A/C
  • Laminopathies

ASJC Scopus subject areas

  • Cell Biology
  • Structural Biology
  • Histology
  • Biochemistry

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