Emerging perspectives on laminopathies

Giovanna Lattanzi, Sara Benedetti, Maria Rosaria Dapice, Lorenzo Maggi, Nicola Carboni, Emanuela Scarano, L. Politano

Research output: Contribution to journalArticlepeer-review


Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

Original languageEnglish
Pages (from-to)25-35
Number of pages11
JournalCell Health and Cytoskeleton
Publication statusPublished - Apr 7 2016


  • Emerin
  • Emery–Dreifuss muscular dystrophy
  • Hutchinson–Gilford progeria
  • Lamin A/C
  • Laminopathies

ASJC Scopus subject areas

  • Cell Biology
  • Structural Biology
  • Histology
  • Biochemistry


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