Emerging perspectives on laminopathies

Giovanna Lattanzi; Sara Benedetti; Maria Rosaria Dapice; Lorenzo Maggi; Nicola Carboni; Emanuela Scarano; L. Politano

doi:10.2147/CHC.S59507

Emerging perspectives on laminopathies

Giovanna Lattanzi, Sara Benedetti, Maria Rosaria Dapice, Lorenzo Maggi, Nicola Carboni, Emanuela Scarano, L. Politano

Research output: Contribution to journal › Article › peer-review

Abstract

Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

Original language	English
Pages (from-to)	25-35
Number of pages	11
Journal	Cell Health and Cytoskeleton
Volume	8
DOIs	https://doi.org/10.2147/CHC.S59507
Publication status	Published - Apr 7 2016

Keywords

Emerin
Emery–Dreifuss muscular dystrophy
Hutchinson–Gilford progeria
Lamin A/C
Laminopathies

ASJC Scopus subject areas

Cell Biology
Structural Biology
Histology
Biochemistry

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abstract = "Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.",

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AU - Lattanzi, Giovanna

AU - Benedetti, Sara

AU - Dapice, Maria Rosaria

AU - Maggi, Lorenzo

AU - Carboni, Nicola

AU - Scarano, Emanuela

AU - Politano, L.

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AB - Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

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KW - Hutchinson–Gilford progeria

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