Emerging perspectives on laminopathies

Giovanna Lattanzi; Sara Benedetti; Maria Rosaria Dapice; Lorenzo Maggi; Nicola Carboni; Emanuela Scarano; L. Politano

doi:10.2147/CHC.S59507

Emerging perspectives on laminopathies

Giovanna Lattanzi, Sara Benedetti, Maria Rosaria Dapice, Lorenzo Maggi, Nicola Carboni, Emanuela Scarano, L. Politano

Research output: Contribution to journal › Article › peer-review

Abstract

Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

Original language	English
Pages (from-to)	25-35
Number of pages	11
Journal	Cell Health and Cytoskeleton
Volume	8
DOIs	https://doi.org/10.2147/CHC.S59507
Publication status	Published - Apr 7 2016

Keywords

Emerin
Emery–Dreifuss muscular dystrophy
Hutchinson–Gilford progeria
Lamin A/C
Laminopathies

ASJC Scopus subject areas

Cell Biology
Structural Biology
Histology
Biochemistry

Access to Document

10.2147/CHC.S59507

Cite this

@article{1910ba3621d646e5ba4df0e63832210f,

title = "Emerging perspectives on laminopathies",

abstract = "Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.",

keywords = "Emerin, Emery–Dreifuss muscular dystrophy, Hutchinson–Gilford progeria, Lamin A/C, Laminopathies",

author = "Giovanna Lattanzi and Sara Benedetti and Dapice, {Maria Rosaria} and Lorenzo Maggi and Nicola Carboni and Emanuela Scarano and L. Politano",

year = "2016",

month = apr,

day = "7",

doi = "10.2147/CHC.S59507",

language = "English",

volume = "8",

pages = "25--35",

journal = "Cell Health and Cytoskeleton",

issn = "1179-1330",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Emerging perspectives on laminopathies

AU - Lattanzi, Giovanna

AU - Benedetti, Sara

AU - Dapice, Maria Rosaria

AU - Maggi, Lorenzo

AU - Carboni, Nicola

AU - Scarano, Emanuela

AU - Politano, L.

PY - 2016/4/7

Y1 - 2016/4/7

N2 - Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

AB - Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.

KW - Emerin

KW - Emery–Dreifuss muscular dystrophy

KW - Hutchinson–Gilford progeria

KW - Lamin A/C

KW - Laminopathies

UR - http://www.scopus.com/inward/record.url?scp=84962855664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962855664&partnerID=8YFLogxK

U2 - 10.2147/CHC.S59507

DO - 10.2147/CHC.S59507

M3 - Article

VL - 8

SP - 25

EP - 35

JO - Cell Health and Cytoskeleton

JF - Cell Health and Cytoskeleton

SN - 1179-1330

ER -

Emerging perspectives on laminopathies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this