Abstract
Laminopathies are a group of inherited disorders caused by mutations in the lamin A/C gene, and can affect diverse organs or tissues, or can be systemic, causing premature aging. In the present review, we report on the composition and structure of the nuclear lamina and the role of lamins in nuclear mechanics and their involvement in human diseases, and provide some examples of laminopathies and current therapeutic approaches.
Original language | English |
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Pages (from-to) | 25-35 |
Number of pages | 11 |
Journal | Cell Health and Cytoskeleton |
Volume | 8 |
DOIs | |
Publication status | Published - Apr 7 2016 |
Keywords
- Emerin
- Emery–Dreifuss muscular dystrophy
- Hutchinson–Gilford progeria
- Lamin A/C
- Laminopathies
ASJC Scopus subject areas
- Cell Biology
- Structural Biology
- Histology
- Biochemistry