Emerging role of capecitabine in gastric cancer

Pasquale Comella, Luca Franco, Rossana Casaretti, Simona De Portu, Enrica Menditto

Research output: Contribution to journalArticlepeer-review

Abstract

For many years, a regimen of fluorouracil and cisplatin has been the standard of care for the treatment of patients with metastatic gastric cancer. More recently, triplet regimens that incorporate fluorouracil and cisplatin with epirubicin (ECF) or docetaxel are being used in the management of patients with metastatic disease; ECF is also being used as preoperative treatment of resectable disease. Capecitabine, a prodrug of fluorouracil that can be taken orally, has been assessed as an alternative to intravenous fluorouracil and has demonstrated noninferiority to its parent compound. Several trials have demonstrated the safety and efficacy of regimens combining capecitabine with other known active drugs against gastric cancer in doublet and triplet combinations. Oral capecitabine appears to be more convenient to administer than infused fluorouracil because it may obviate the need for central venous access and its associated risk of complications. All of these findings support consideration of capecitabine among the available drug treatment options for patients with metastatic and those with operable gastric cancers.

Original languageEnglish
Pages (from-to)318-330
Number of pages13
JournalPharmacotherapy
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Capecitabine
  • Gastric cancer
  • Therapeutic management

ASJC Scopus subject areas

  • Pharmacology (medical)

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