Abstract
The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-/) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received GW0742 (0.3mg/kg, 10 DMSO, i.p. after the ligature placement and daily for eight days). At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed. One the eighth day after placement of the ligature, we evaluated (1) NF-B expression, (2) cytokines expression, (3) iNOS expression, (5) the nitration of tyrosine, (6) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of GW0742 significantly decreased all of the parameters of inflammation as described above. Taken together, these results demonstrate that GW0742 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.
| Original language | English |
|---|---|
| Article number | 787159 |
| Journal | Mediators of Inflammation |
| Volume | 2011 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
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Emerging role of PPAR-β/δ in inflammatory process associated to experimental periodontitis. / Di Paola, Rosanna; Briguglio, Francesco; Paterniti, Irene; Mazzon, Emanuela; Oteri, Giacomo; Militi, David; Cordasco, Giancarlo; Cuzzocrea, Salvatore.
In: Mediators of Inflammation, Vol. 2011, 787159, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emerging role of PPAR-β/δ in inflammatory process associated to experimental periodontitis
AU - Di Paola, Rosanna
AU - Briguglio, Francesco
AU - Paterniti, Irene
AU - Mazzon, Emanuela
AU - Oteri, Giacomo
AU - Militi, David
AU - Cordasco, Giancarlo
AU - Cuzzocrea, Salvatore
PY - 2011
Y1 - 2011
N2 - The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-/) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received GW0742 (0.3mg/kg, 10 DMSO, i.p. after the ligature placement and daily for eight days). At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed. One the eighth day after placement of the ligature, we evaluated (1) NF-B expression, (2) cytokines expression, (3) iNOS expression, (5) the nitration of tyrosine, (6) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of GW0742 significantly decreased all of the parameters of inflammation as described above. Taken together, these results demonstrate that GW0742 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.
AB - The aim of the present study was to evaluate the contribution of peroxisome proliferator-activated receptor (PPAR-/) in animal model of periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received GW0742 (0.3mg/kg, 10 DMSO, i.p. after the ligature placement and daily for eight days). At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed. One the eighth day after placement of the ligature, we evaluated (1) NF-B expression, (2) cytokines expression, (3) iNOS expression, (5) the nitration of tyrosine, (6) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of GW0742 significantly decreased all of the parameters of inflammation as described above. Taken together, these results demonstrate that GW0742 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.
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UR - http://www.scopus.com/inward/citedby.url?scp=84855179620&partnerID=8YFLogxK
U2 - 10.1155/2011/787159
DO - 10.1155/2011/787159
M3 - Article
C2 - 22131647
AN - SCOPUS:84855179620
VL - 2011
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
M1 - 787159
ER -