TY - JOUR
T1 - Emerging Role of Semaphorins as Major Regulatory Signals and Potential Therapeutic Targets in Cancer
AU - Tamagnone, Luca
PY - 2012/8/14
Y1 - 2012/8/14
N2 - Semaphorins are mainly known as guidance signals in development, acting through receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation of tumor angiogenesis, tumor growth, cancer cell invasiveness, and metastatic spreading. Intriguingly, activated plexins can transactivate receptor tyrosine kinases, such as MET, VEGFR2, FGFR2, and ERBB2, and lead to distinctive effects in a cell-context-dependent manner. Moreover, certain semaphorins concomitantly target endothelial and cancer cells, and can achieve remarkable inhibition of angiogenesis and tumor growth, associated with anti-metastatic activity. Altogether, these data validate the identification of semaphorin signals as promising therapeutic targets in cancer.
AB - Semaphorins are mainly known as guidance signals in development, acting through receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation of tumor angiogenesis, tumor growth, cancer cell invasiveness, and metastatic spreading. Intriguingly, activated plexins can transactivate receptor tyrosine kinases, such as MET, VEGFR2, FGFR2, and ERBB2, and lead to distinctive effects in a cell-context-dependent manner. Moreover, certain semaphorins concomitantly target endothelial and cancer cells, and can achieve remarkable inhibition of angiogenesis and tumor growth, associated with anti-metastatic activity. Altogether, these data validate the identification of semaphorin signals as promising therapeutic targets in cancer.
UR - http://www.scopus.com/inward/record.url?scp=84865137629&partnerID=8YFLogxK
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U2 - 10.1016/j.ccr.2012.06.031
DO - 10.1016/j.ccr.2012.06.031
M3 - Article
C2 - 22897846
AN - SCOPUS:84865137629
VL - 22
SP - 145
EP - 152
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 2
ER -