Emerging role of vitamin D in autoimmune diseases

An update on evidence and therapeutic implications

Giuseppe Murdaca, Alessandro Tonacci, Simone Negrini, Monica Greco, Matteo Borro, Francesco Puppo, Sebastiano Gangemi

Research output: Contribution to journalReview article

Abstract

Vitamin D plays a key role in in calcium homeostasis and, thus, provides an important support in bone growth by aiding in the mineralization of the collagen matrix. However, vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and anti-fibrotic actions. Autoimmune diseases result from an aberrant activation of the immune system, whereby the immune response is directed against harmless self-antigens. Does vitamin D play a role in the pathophysiology of autoimmune diseases? And, if so, what is its role? In the last decade, researchers’ interest in vitamin D and its correlations with autoimmune diseases has considerably increased. We conducted a literature review, covering the period January 1, 2009 through March 30, 2019, in PubMed. We analyzed more than 130 studies in order to find a correlation between vitamin D levels and its effect upon several autoimmune diseases. The analysis demonstrated an inverse association between vitamin D and the development of several autoimmune diseases, such as SLE, thyrotoxicosis, type 1 DM, MS, iridocyclitis, Crohn's disease, ulcerative colitis, psoriasis vulgaris, seropositive RA, polymyalgia rheumatica. International multicenter study could allow us to confirm the data already present in the literature in the single clinical studies and to evaluate when to effectively supplement vitamin D in patients who do not take corticosteroids.

Original languageEnglish
Article number102350
JournalAutoimmunity Reviews
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Vitamin D
Autoimmune Diseases
Therapeutics
Iridocyclitis
Polymyalgia Rheumatica
Thyrotoxicosis
Bone Development
Autoantigens
Ulcerative Colitis
Psoriasis
PubMed
Crohn Disease
Multicenter Studies
Immune System
Adrenal Cortex Hormones
Homeostasis
Anti-Inflammatory Agents
Collagen
Antioxidants
Research Personnel

Keywords

  • autoimmune disease
  • autoimmunity
  • immunomodulation
  • vitamin D
  • vitamin D deficiency
  • vitamin D receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Emerging role of vitamin D in autoimmune diseases : An update on evidence and therapeutic implications. / Murdaca, Giuseppe; Tonacci, Alessandro; Negrini, Simone; Greco, Monica; Borro, Matteo; Puppo, Francesco; Gangemi, Sebastiano.

In: Autoimmunity Reviews, 01.01.2019.

Research output: Contribution to journalReview article

Murdaca, Giuseppe ; Tonacci, Alessandro ; Negrini, Simone ; Greco, Monica ; Borro, Matteo ; Puppo, Francesco ; Gangemi, Sebastiano. / Emerging role of vitamin D in autoimmune diseases : An update on evidence and therapeutic implications. In: Autoimmunity Reviews. 2019.
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