Emerging roles for Polycomb proteins in cancer

Diego Pasini, Luciano Di Croce

Research output: Contribution to journalArticle

Abstract

The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume36
DOIs
Publication statusPublished - Feb 1 2016

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ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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