Emerging roles of microRNAs in cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNAs (miRNAs) have emerged as important regulators of human carcinogenesis by affecting the expression of key oncogenes and tumor suppressor genes. MiRNAs elicit their function through post-transcriptional regulation of the mRNA translation into protein as well as functioning as ligands for proteic receptors called miRceptors. Our understanding of the role of miRNAs in cancer biology has enormously improved in the last few years, providing the rationale for new therapeutics. Here we discuss the most recent findings on the role of miRNAs in modulating cancer biology with a specific focus on their role as modulators of the biology of the tumor microenvironment both as cargo of extracellular vesicles and as extra-vesicular miRNAs.

Original languageEnglish
Pages (from-to)128-133
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume48
DOIs
Publication statusPublished - Feb 1 2018

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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