Abstract
Protease-activated receptors (PARs) are a class of G protein-coupled receptors (GPCRs) with a unique mechanism of activation, prompted by a proteolytic cleavage in their N-terminal domain that uncovers a tethered ligand, which binds and stimulates the same receptor. PARs subtypes (PAR1- 4) have well-documented roles in coagulation, hemostasis, and inflammation, and have been deeply investigated for their function in cellular survival/degeneration, while their roles in the brain in physiological conditions remain less appreciated. Here, we describe PARs’ effects in the modulation of neurotransmission and synaptic plasticity. Available evidence, mainly concerning PAR1-mediated and PAR2-mediated regulation of glutamatergic and GABAergic transmission, supports that PARs are important modulators of synaptic efficacy and plasticity in normal conditions.
Original language | English |
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Article number | 869 |
Pages (from-to) | 1-13 |
Number of pages | 13 |
Journal | International Journal of Molecular Sciences |
Volume | 22 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 2 2021 |
Keywords
- GABA
- Glutamate
- Matrix metalloproteases
- Protease-activated receptors
- Serine proteases
- Synaptic plasticity
- Synaptic transmission
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry