Emerging targets in pituitary adenomas: Role of the CXCL12/CXCR4-R7 system

Federica Barbieri, Stefano Thellung, Roberto Würth, Federico Gatto, Alessandro Corsaro, Valentina Villa, Mario Nizzari, Manuela Albertelli, Diego Ferone, Tullio Florio

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer. Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development. In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases. CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12. Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported. Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion. In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis. Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.

Original languageEnglish
Article number753524
JournalInternational Journal of Endocrinology
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Pituitary Neoplasms
Chemokines
CXCR4 Receptors
Chemokine CXCL12
Chemokine Receptors
Neurogenesis
Synaptic Transmission
Neuroglia
Cell Movement
Signal Transduction
Cell Survival
Carcinogenesis
Central Nervous System
Endothelial Cells
Cell Proliferation
Pharmacology
Cytokines
Inflammation
Neurons
Brain

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Barbieri, F., Thellung, S., Würth, R., Gatto, F., Corsaro, A., Villa, V., ... Florio, T. (2014). Emerging targets in pituitary adenomas: Role of the CXCL12/CXCR4-R7 system. International Journal of Endocrinology, 2014, [753524]. https://doi.org/10.1155/2014/753524

Emerging targets in pituitary adenomas : Role of the CXCL12/CXCR4-R7 system. / Barbieri, Federica; Thellung, Stefano; Würth, Roberto; Gatto, Federico; Corsaro, Alessandro; Villa, Valentina; Nizzari, Mario; Albertelli, Manuela; Ferone, Diego; Florio, Tullio.

In: International Journal of Endocrinology, Vol. 2014, 753524, 2014.

Research output: Contribution to journalArticle

Barbieri, F, Thellung, S, Würth, R, Gatto, F, Corsaro, A, Villa, V, Nizzari, M, Albertelli, M, Ferone, D & Florio, T 2014, 'Emerging targets in pituitary adenomas: Role of the CXCL12/CXCR4-R7 system', International Journal of Endocrinology, vol. 2014, 753524. https://doi.org/10.1155/2014/753524
Barbieri, Federica ; Thellung, Stefano ; Würth, Roberto ; Gatto, Federico ; Corsaro, Alessandro ; Villa, Valentina ; Nizzari, Mario ; Albertelli, Manuela ; Ferone, Diego ; Florio, Tullio. / Emerging targets in pituitary adenomas : Role of the CXCL12/CXCR4-R7 system. In: International Journal of Endocrinology. 2014 ; Vol. 2014.
@article{8adc15fd520a4eb0ab3de895ecea3e66,
title = "Emerging targets in pituitary adenomas: Role of the CXCL12/CXCR4-R7 system",
abstract = "Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer. Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development. In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases. CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12. Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported. Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion. In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis. Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.",
author = "Federica Barbieri and Stefano Thellung and Roberto W{\"u}rth and Federico Gatto and Alessandro Corsaro and Valentina Villa and Mario Nizzari and Manuela Albertelli and Diego Ferone and Tullio Florio",
year = "2014",
doi = "10.1155/2014/753524",
language = "English",
volume = "2014",
journal = "International Journal of Endocrinology",
issn = "1687-8337",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Emerging targets in pituitary adenomas

T2 - Role of the CXCL12/CXCR4-R7 system

AU - Barbieri, Federica

AU - Thellung, Stefano

AU - Würth, Roberto

AU - Gatto, Federico

AU - Corsaro, Alessandro

AU - Villa, Valentina

AU - Nizzari, Mario

AU - Albertelli, Manuela

AU - Ferone, Diego

AU - Florio, Tullio

PY - 2014

Y1 - 2014

N2 - Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer. Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development. In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases. CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12. Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported. Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion. In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis. Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.

AB - Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer. Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development. In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases. CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12. Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported. Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion. In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis. Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.

UR - http://www.scopus.com/inward/record.url?scp=84914688988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84914688988&partnerID=8YFLogxK

U2 - 10.1155/2014/753524

DO - 10.1155/2014/753524

M3 - Article

AN - SCOPUS:84914688988

VL - 2014

JO - International Journal of Endocrinology

JF - International Journal of Endocrinology

SN - 1687-8337

M1 - 753524

ER -