Emerging treatments in Parkinson's disease

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Abstract

This paper provides a critical review on the most recent developments in the treatment of Parkinson's disease. New symptomatic therapies include the use of catechol-O-methyltransferase (COMT) inhibitors, new dopamine agonists and of surgical treatments (such as pallidotomy or deep brain stimulation). Protective strategies include the use of COMT and monoamine oxidase B inhibitors, of dopamine agonists and of trophic factors. The main preclinical premises, on which the usage of newly developed therapies is based, are discussed. Symptomatic therapy has been greatly refined in recent years and has gradually become a polytherapeutic approach. Protective therapy, which will attract the interest of fundamental and clinical research in the field of Parkinson's disease, is the real future challenge.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalEuropean Neurology
Volume38
Issue number3
Publication statusPublished - Oct 1997

Keywords

  • Dopamine
  • Dopamine agonists
  • Glutamate
  • Levodopa
  • Parkinson's disease
  • Receptors
  • Therapy

ASJC Scopus subject areas

  • Clinical Neurology

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