Emerging Tumor Entities and Variants of CNS Neoplasms

Giovanna Cenacchi, Felice Giangaspero

Research output: Contribution to journalArticlepeer-review

Abstract

Since the appearance in 2000 of the World Health Organization (WHO) classification for central nervous system (CNS) neoplasms, numerous descriptions of new entities or variants have appeared in the literature. In the group of neuronal and mixed glioneuronal neoplasms are lesions with distinctive morphological features that are still not included in a precise classification, including extraventricular neurocytoma, papillary glioneuronal tumor, rosette-forming glioneuronal of the fourth ventricle, glioneuronal with neuropil-like rosette, and DNT-like tumor of the septum pellucidum. The glioneuronal tumor with neuropil-like rosette and oligodendroglioma with neurocytic differentiation represent morphological variants of genetically proven diffuse gliomas. The lipoastrocytoma and the pilomixoid astrocytoma enlarge the group of astrocytic lesions. Rare, low-grade gliomas of the spinal cord with extensive leptomeningeal dissemination associated with unusual neuroimaging are described. The chordoid glioma of the third ventricle and the papillary tumor of the pineal region seem to be correlated by a common histogenesis from the specialized ependyma of the subcommissural organ. An embryonal tumor with neuropil and true rosettes combining features of neuroblastoma and ependymoblastoma is discussed. These new, recently described lesions indicate that the complex morphologic spectrum of CNS tumors is far from being completely delineated.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalJournal of Neuropathology and Experimental Neurology
Volume63
Issue number3
Publication statusPublished - Mar 2004

Keywords

  • Low-grade spinal cord tumor with lepromeningeal dissemination
  • Neuroglial neoplasm
  • Papillary neuroglial neoplasm
  • Papillary tumor of the pineal region
  • Rosette-forming neuroglial tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Emerging Tumor Entities and Variants of CNS Neoplasms'. Together they form a unique fingerprint.

Cite this