Emerin increase in regenerating muscle fibers.

S. Squarzoni, P. Sabatelli, C. Capanni, G. Lattanzi, C. Rutigliano, M. Columbaro, E. Mattioli, M. Rocca, N. M. Maraldi

Research output: Contribution to journalArticle

Abstract

The fate of emerin during skeletal muscle regeneration was investigated in an animal model by means of crush injury. Immunofluorescence, immunoblotting and mRNA analysis demonstrated that emerin level is increased in regenerating rat muscle fibers with respect to normal mature myofibers. This finding suggests an involvement of emerin during the muscle fiber regeneration process, in analogy with its reported involvement in muscle cell differentiation in vitro. The impairment of skeletal muscle physiological regeneration or reorganization could be a possible pathogenetic mechanism for Emery Dreifuss muscular dystrophy.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalEuropean journal of histochemistry : EJH
Volume49
Issue number4
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

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