Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats

Lucia A. Ruocco, Emilia Romano, Concetta Treno, Enza lacivita, Arra Claudio, Ugo A. Gironi-Carnevale, Domenica Travaglini, Marcello Leopoldo, Giovanni Laviola, Adolfo G. Sadile, Walter Adriani

Research output: Contribution to journalArticlepeer-review

Abstract

We report here the results of studies aimed to investigate the involvement of serotonin receptor 7 subtype (5-HT7-R) in the modulation of emotional response in Naples High-Excitability (NHE) rat, a validated model for hyperactivity and impaired attention. A range of dosages (0.0, 0.125, 0.250, or 0.500 mg/kg) of LP-211, a selective agonist of 5-HT7-Rs, has been evaluated in animals at different age (adolescence and adulthood). Male NHE and random bred (NRB) control rats were tested in an Elevated Zero-Maze (EZM) after LP-211 treatment in two different regimens: at the issue of adolescent, subchronic exposure (14 intraperitoneal [i.p.] injections, once/day, pnd 31-44, tested on pnd 45-Exp. 1) or as adult, acute effect (15 min after i.p. injection-Exp. 2). Adolescent, subchronic LP-211 at 0.500 mg/kg dosage increased the frequency of head-dips only in NHE rats. Drug effect on time spent and entries in open EZM quadrants were revealed with adult, acute administration of 0.125 mg/kg LP-211 (both strains), indicating a tendency toward anxiolytic effects. In conclusion, data demonstrate that subchronic stimulation of 5-HT7-Rs during prepuberal period increases novelty-seeking/risk-taking propensity in NHE adults. These sequels are revealing increased disinhibition and/or motivation to explore in the NHE rats, which are characterized by a hyperactive dopaminergic system. These data may open new perspectives in studying mechanism of risk-seeking behavior.

Original languageEnglish
Pages (from-to)159-167
Number of pages9
JournalSynapse
Volume68
Issue number4
DOIs
Publication statusPublished - Apr 2014

Keywords

  • ADHD
  • Hyperactivity
  • LP-211
  • NHE rats
  • Zero maze

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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