Emotional dysregulation and callous unemotional traits as possible predictors of short-term response to methylphenidate monotherapy in drug-naïve youth with ADHD: Comprehensive Psychiatry

G. Masi, P. Fantozzi, P. Muratori, G. Bertolucci, A. Tacchi, A. Villafranca, C. Pfanner, S. Cortese

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Emotional dysregulation (ED) and callous unemotional (CU) traits can be associated with ADHD in youth, influencing its natural history and outcome, but their effect on medication efficacy is unexplored. We examined whether two measures of baseline ED and CU traits, the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) and the Antisocial Process Screening Device (APSD), respectively, were predictors of change of ADHD-Rating Scale (ADHD-RS) after a 4-week methylphenidate (MPH) monotherapy. Methods: 43 patients (37 males, 8–16 years, mean 9.9 ± 2.7 years) were included. Hierarchical linear regression models were used to explore whether CBCL-DP and APSD might predict ADHD-RS score, controlling for baseline severity. Results: Baseline CBCL-DP predicted higher post-treatment ADHD-RS scores in total and hyperactivity-impulsivity, but not in inattention subscale. Baseline APSD was not significantly related to ADHD-RS scores at the follow-up. Limitations: Small sample size, lack of gender diversity, non-blind design and short period of observation. Conclusion: ED, assessed with that CBCL-DP, might be a negative predictor of change of hyperactive-impulsive symptoms after MPH treatment and should be systematically assessed at baseline. © 2020 The Author(s)
Original languageEnglish
JournalCompr. Psychiatry
Volume100
DOIs
Publication statusPublished - 2020

Keywords

  • ADHD
  • Callous unemotional traits
  • Children
  • Emotional dysregulation
  • Methylphenidate
  • methylphenidate
  • central stimulant agent
  • adolescent
  • Article
  • attention
  • attention deficit disorder
  • child
  • Child Behavior Checklist
  • clinical article
  • emotion regulation
  • emotionality
  • female
  • follow up
  • human
  • hyperactivity
  • impulsiveness
  • male
  • monotherapy
  • rating scale
  • treatment response
  • antisocial personality disorder
  • cognition
  • drug effect
  • emotion
  • psychology
  • severity of illness index
  • treatment outcome
  • Adolescent
  • Antisocial Personality Disorder
  • Attention Deficit Disorder with Hyperactivity
  • Central Nervous System Stimulants
  • Child
  • Cognition
  • Emotions
  • Female
  • Humans
  • Impulsive Behavior
  • Male
  • Severity of Illness Index
  • Treatment Outcome

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