TY - JOUR
T1 - Emotional impact on the results of BRCA1 and BRCA2 genetic test
T2 - An observational retrospective study
AU - Mella, Sara
AU - Muzzatti, Barbara
AU - Dolcetti, Riccardo
AU - Annunziata, Maria Antonietta
PY - 2017/10/2
Y1 - 2017/10/2
N2 - Background: BRCA1 and BRCA2 mutations are associated with a higher risk of breast and ovarian tumors. This study evaluated the emotional states of women 1 month after having received the results of the genetic test and assessed eventual associations with the type of outcome, personal/familiar disease history and major socio-demographic variables. Methods: The study, an observational retrospective one, involved 91 women, evaluated 1 month after receiving their results. Patients were administered the Hospital Anxiety and Depression Scale, the Profile of Mood States and emotional Thermometers. Results: Anxiety was significantly higher than depression (p < 0.001), and 21.3% and 21.3% of the sample were, respectively, possible and probable cases for anxiety, whereas 13.5% and 10.1% were possible and probable cases for depression. Within the six mood states, Confusion-Bewilderment (M = 48.5) was the lowest, whereas Fatigue-Inertia (M = 52.3) was the highest. Differences were recorded within the ten assessed emotions too. Being a proband/nonproband and being or not a cancer patient were associated with many tested variables. Conclusion: The psycho-emotional screening of women undertaking genetic counseling is relevant and should cover a large range of dimensions.
AB - Background: BRCA1 and BRCA2 mutations are associated with a higher risk of breast and ovarian tumors. This study evaluated the emotional states of women 1 month after having received the results of the genetic test and assessed eventual associations with the type of outcome, personal/familiar disease history and major socio-demographic variables. Methods: The study, an observational retrospective one, involved 91 women, evaluated 1 month after receiving their results. Patients were administered the Hospital Anxiety and Depression Scale, the Profile of Mood States and emotional Thermometers. Results: Anxiety was significantly higher than depression (p < 0.001), and 21.3% and 21.3% of the sample were, respectively, possible and probable cases for anxiety, whereas 13.5% and 10.1% were possible and probable cases for depression. Within the six mood states, Confusion-Bewilderment (M = 48.5) was the lowest, whereas Fatigue-Inertia (M = 52.3) was the highest. Differences were recorded within the ten assessed emotions too. Being a proband/nonproband and being or not a cancer patient were associated with many tested variables. Conclusion: The psycho-emotional screening of women undertaking genetic counseling is relevant and should cover a large range of dimensions.
KW - BRCA1/2
KW - Emotions
KW - Genetic counseling
KW - Mood states
KW - Psychological distress
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U2 - 10.1186/s13053-017-0077-6
DO - 10.1186/s13053-017-0077-6
M3 - Article
AN - SCOPUS:85030689801
VL - 15
JO - Hereditary Cancer in Clinical Practice
JF - Hereditary Cancer in Clinical Practice
SN - 1731-2302
IS - 1
M1 - 16
ER -