Abstract
The amikacin-carbenicillincotrimoxazole combination was used as an empiric treatment for febrile episodes in patients with acute leukemia and severe granulocytopenia. The choice of drugs was based on finding in our institute that the majority of infections are caused by gram-negative rods, particularly Pseudomonas, with high percentage of strains resistant to gentamycin and tobramycin. Granulocyte transfusions were given to the patients who did not show satisfactory clinical improvement 48 h after start of antibiotic therapy. There were cures in 84.6% of the febrile episodes treated with this antibiotic combination, including five of eight episodes of microbiologically confirmed bacteremia. Survival after 21 days of antibiotic therapy amounted to 89.1%. Renal toxicity occurred in 10.9% of the episodes treated. The prompt use of this antibiotic combination seems to be a safe and efficacious therapeutic tool for treating these high-risk patients.
| Original language | English |
|---|---|
| Pages (from-to) | 520-523 |
| Number of pages | 4 |
| Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
| Volume | 20 |
| Issue number | 11 |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Toxicology
Cite this
Empiric treatment of infections in granulocytopenic patients with acute leukemia : A study of amikacin-carbenicillin-cotrimoxazole. / Cortelezzi, A.; Radaelli, F.; Penagini, R.; Pogliani, E. M.
In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 20, No. 11, 1982, p. 520-523.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Empiric treatment of infections in granulocytopenic patients with acute leukemia
T2 - A study of amikacin-carbenicillin-cotrimoxazole
AU - Cortelezzi, A.
AU - Radaelli, F.
AU - Penagini, R.
AU - Pogliani, E. M.
PY - 1982
Y1 - 1982
N2 - The amikacin-carbenicillincotrimoxazole combination was used as an empiric treatment for febrile episodes in patients with acute leukemia and severe granulocytopenia. The choice of drugs was based on finding in our institute that the majority of infections are caused by gram-negative rods, particularly Pseudomonas, with high percentage of strains resistant to gentamycin and tobramycin. Granulocyte transfusions were given to the patients who did not show satisfactory clinical improvement 48 h after start of antibiotic therapy. There were cures in 84.6% of the febrile episodes treated with this antibiotic combination, including five of eight episodes of microbiologically confirmed bacteremia. Survival after 21 days of antibiotic therapy amounted to 89.1%. Renal toxicity occurred in 10.9% of the episodes treated. The prompt use of this antibiotic combination seems to be a safe and efficacious therapeutic tool for treating these high-risk patients.
AB - The amikacin-carbenicillincotrimoxazole combination was used as an empiric treatment for febrile episodes in patients with acute leukemia and severe granulocytopenia. The choice of drugs was based on finding in our institute that the majority of infections are caused by gram-negative rods, particularly Pseudomonas, with high percentage of strains resistant to gentamycin and tobramycin. Granulocyte transfusions were given to the patients who did not show satisfactory clinical improvement 48 h after start of antibiotic therapy. There were cures in 84.6% of the febrile episodes treated with this antibiotic combination, including five of eight episodes of microbiologically confirmed bacteremia. Survival after 21 days of antibiotic therapy amounted to 89.1%. Renal toxicity occurred in 10.9% of the episodes treated. The prompt use of this antibiotic combination seems to be a safe and efficacious therapeutic tool for treating these high-risk patients.
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M3 - Article
C2 - 6983502
AN - SCOPUS:0019920078
VL - 20
SP - 520
EP - 523
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
SN - 0174-4879
IS - 11
ER -