eMSQOL-29: Prospective validation of the abbreviated, electronic version of MSQOL-54

Rosalba Rosato, Silvia Testa, Antonio Bertolotto, Francesco Scavelli, Ambra M. Giovannetti, Paolo Confalonieri, Francesco Patti, Clara Grazia Chisari, Alessandra Lugaresi, Erika Pietrolongo, Maria Grazia Grasso, Ilaria Rossi, Anna Toscano, Barbara Loera, Andrea Giordano, Alessandra Solari

Research output: Contribution to journalArticlepeer-review


Background: We recently devised a shortened version of the 54-item Multiple Sclerosis Quality of Life (MSQOL-54) in paper (MSQOL-29, consisting of 25 items forming 7 subscales and 4 single items, and one filter question for 3 ‘sexual function’ items) and electronic format (eMSQOL-29). Objectives: To prospectively assess eMSQOL-29 psychometric properties, acceptability/equivalence versus MSQOL-29. Methods: Multiple sclerosis (MS) patients (n = 623; Expanded Disability Status Scale (EDSS) range 0.0–9.0) completed eMSQOL-29, Hospital Anxiety and Depression Scale, Functional Assessment of MS (FAMS), European Quality of life Five Dimensions-3L, and received EDSS and Symbol Digit Modalities Test (SDMT). Equivalence versus MSQOL-29 was assessed in 242 patients (randomized cross-over design). Results: ‘Sexual function’ items were filtered out by 273 patients (47%). No multi-item scale had floor effect, while five had ceiling effect. Cronbach’s alpha range was 0.88–0.90. Confirmatory factor analysis showed good overall fit and the two-factor solution for composite scores was confirmed. Criterion validity was sub-optimal for ‘cognitive function’ (vs SDMT, r = 0.25) and ‘social function’ (vs FAMS social function, r = 0.38). eMSQOL-29 equivalence was confirmed and its acceptability was good. Conclusion: eMSQOL-29 showed good internal consistency, factor structure and no floor effect, while most subscales had some ceiling effect. Criterion validity was sub-optimal for two subscales. Equivalence and acceptability were good.

Original languageEnglish
JournalMultiple Sclerosis Journal
Publication statusE-pub ahead of print - May 1 2018


  • electronic migration
  • Health-related quality of life
  • MSQOL-54
  • multiple sclerosis
  • patient reported outcomes
  • psychometric assessment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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