EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons

Paola Briata, Erica Di Blas, Massimo Gulisano, Antonello Mallamaci, Raffaella Iannone, Edoardo Boncinelli, Giorgio Corte

Research output: Contribution to journalArticle

Abstract

We analyzed the distribution of EMX1 during mouse development. EMX1 is a homeoprotein encoded by Emx1, a regulatory homeobox gene expressed in the developing forebrain. Its distribution essentially overlaps the expression domains of Emx1 transcripts. The EMX1 protein is present in the developing dorsal telencephalon, that is, in the cerebral cortex, olfactory bulb and hippocampus. In the cerebral cortex EMX1 is present in nuclei of proliferating, differentiating and most mature neurons belonging to all cortical layers. In the olfactory bulb it is present in all proliferating cells during development, whereas postnatally it is faintly expressed in some mitral cells. Non-cerebral localizations include a transient expression in branchial pouches, in the apical ectodermal ridge of the developing limbs and in the developing kidney. Of particular interest is the presence of EMX1 in the olfactory nerve from its first appearance during embryogenesis to birth. The protein is present in axons of olfactory sensory neurons along their entire length, including their terminals in spherical regions of neuropil in the olfactory bulb called glomeruli.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalMechanisms of Development
Volume57
Issue number2
DOIs
Publication statusPublished - Jul 1996

Fingerprint

Olfactory Receptor Neurons
Homeodomain Proteins
Olfactory Bulb
Cell Nucleus
Cerebral Cortex
Axons
Olfactory Nerve
Telencephalon
Neuropil
Homeobox Genes
Regulator Genes
Prosencephalon
Embryonic Development
Hippocampus
Proteins
Extremities
Parturition
Kidney
Neurons

Keywords

  • Cerebral cortex
  • EMX1
  • Homeoprotein
  • Olfactory nerve

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons. / Briata, Paola; Di Blas, Erica; Gulisano, Massimo; Mallamaci, Antonello; Iannone, Raffaella; Boncinelli, Edoardo; Corte, Giorgio.

In: Mechanisms of Development, Vol. 57, No. 2, 07.1996, p. 169-180.

Research output: Contribution to journalArticle

Briata, Paola ; Di Blas, Erica ; Gulisano, Massimo ; Mallamaci, Antonello ; Iannone, Raffaella ; Boncinelli, Edoardo ; Corte, Giorgio. / EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons. In: Mechanisms of Development. 1996 ; Vol. 57, No. 2. pp. 169-180.
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