Emx2 as a novel tool to suppress glioblastoma

Carmen Falcone, Antonio Daga, Giampiero Leanza, Antonello Mallamaci

Research output: Contribution to journalArticle

Abstract

Glioblastoma is a devastating CNS tumour for which no cure is presently available. We wondered if manipulation of Emx2, which normally antagonizes cortico-cerebral astrogenesis by inhibiting proliferation of astrocyte progenitors, may be employed to counteract it. We found that Emx2 overexpression induced the collapse of seven out of seven in vitro tested glioblastoma cell lines. Moreover, it suppressed four out of four of these lines in vivo. As proven by dedicated rescue assays, the antioncogenic activity of Emx2 originated from its impact on at least six metabolic nodes, which accounts for the robustness of its effect. Finally, in two out of two tested lines, the tumor culture collapse was also achieved when Emx2 was driven by a neural stem cell-specific promoter, likely active within tumor-initiating cells. All that points to Emx2 as a novel, promising tool for therapy of glioblastoma and prevention of its recurrencies.

Original languageEnglish
Pages (from-to)41005-41016
Number of pages12
JournalOncotarget
Volume7
Issue number27
DOIs
Publication statusPublished - Jul 5 2016

Keywords

  • Journal Article

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    Falcone, C., Daga, A., Leanza, G., & Mallamaci, A. (2016). Emx2 as a novel tool to suppress glioblastoma. Oncotarget, 7(27), 41005-41016. https://doi.org/10.18632/oncotarget.9322