Emx2 promotes symmetric cell divisions and a multipotential fate in precursors from the cerebral cortex

Nico Heins, Federico Cremisi, Paolo Malatesta, Rosaria M R Gangemi, Giorgio Corte, Jack Price, Guy Goudreau, Peter Gruss, Magdalena Götz

Research output: Contribution to journalArticlepeer-review

Abstract

Distinct sets of precursor cells generate the mammalian cerebral cortex. During neurogenesis most precursors are specified to generate a single cell type and only few are multipotent. The cell-intrinsic molecular determinants of these distinct lineages are not known. Here we describe that retroviral transduction of the transcription factor Emx2 in precursors from the cerebral cortex results in a significant increase of large clones that are generated mostly by symmetric cell divisions and contain multiple cell types, comprising neurons and glial cells. Thus, Emx2 is the first cell-intrinsic determinant able to instruct CNS precursors towards a multipotential fate. To evaluate the role of endogenous Emx2 in cortical precursors, we examined cell division in Emx2-/- mice. These analyses further supported the role of endogenous Emx2 in the regulation of symmetric cell divisions in the developing cortex.

Original languageEnglish
Pages (from-to)485-502
Number of pages18
JournalMolecular and Cellular Neuroscience
Volume18
Issue number5
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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