En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine

R Charest-Morin, Charles G. Fisher, Peter Pal Varga, Ziya L. Gokaslan, Laurence D. Rhines, Jeremy J. Reynolds, Mark B. Dekutoski, N. A. Quraishi, Mark H. Bilsky, Michael G. Fehlings, D Chou, Niccole M. Germscheid, Alessandro Luzzati, Stefano Boriani

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Abstract

STUDY DESIGN Multicenter, ambispective observational study OBJECTIVE.: To quantify local recurrence and mortality rates after surgical treatment of spinal giant cell tumor and to determine whether en bloc resection with wide/marginal margins is associated with improved prognosis compared to an intra-lesional procedure. SUMMARY OF BACKGROUND DATA Giant cell tumor of the spine is a rare primary bone tumor known for its local aggressiveness. Optimal surgical treatment remains to be determined. METHODS The AOSpine Knowledge Forum Tumor developed a comprehensive multicenter database including demographics, presentation, diagnosis, treatment, mortality, and recurrence rate data for giant cell tumor of the spine. Patients were analysed based on surgical margins, including Enneking appropriateness. RESULTS Between 1991 and 2011, 82 patients underwent surgery for spinal giant cell tumor. According to the Enneking classification, 59 (74%) tumors were classified as S3-aggressive and 21 (26%) as S2-active. The surgical margins were wide/ marginal in 27 (36%) patients and intra-lesional in 48 (64%) patients. 39/77 (51%) underwent Enneking appropriate (EA) treatment and 38 (49%) underwent Enneking inappropriate (EI) treatment. Eighteen (22%) patients experienced local recurrence (LR). LR occurred in 11 (29%) EI-treated patients and 6 (15%) EA-treated patients (p = 0.151). There was a significant difference between wide/marginal margins and intra-lesional margins for LR (p = 0.029). Seven (9%) patients died. LR is strongly associated with death (RR 8.9, p < 0.001). Six (16%) EI-treated patients and one (3%) EA-treated patient died (p = 0.056). With regards to surgical margins, all patients who died underwent intra-lesional resection (p = 0.096). CONCLUSION En bloc resection with wide/marginal margins should be performed when technically feasible because it is associated with decreased LR. Intra-lesional resection is associated with increased LR, and mortality correlates with LR.
Original languageEnglish
Pages (from-to)1383-1390
Number of pages8
JournalSpine
Volume42
Issue number18
DOIs
Publication statusPublished - Jan 2017

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Giant Cell Tumors
Spine
Recurrence
Therapeutics
Mortality
Neoplasms
Observational Studies
Demography
Databases

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Charest-Morin, R., Fisher, C. G., Varga, P. P., Gokaslan, Z. L., Rhines, L. D., Reynolds, J. J., ... Boriani, S. (2017). En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. Spine, 42(18), 1383-1390. https://doi.org/10.1097/BRS.0000000000002094

En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. / Charest-Morin, R; Fisher, Charles G.; Varga, Peter Pal; Gokaslan, Ziya L.; Rhines, Laurence D.; Reynolds, Jeremy J.; Dekutoski, Mark B.; Quraishi, N. A.; Bilsky, Mark H.; Fehlings, Michael G.; Chou, D; Germscheid, Niccole M.; Luzzati, Alessandro; Boriani, Stefano.

In: Spine, Vol. 42, No. 18, 01.2017, p. 1383-1390.

Research output: Contribution to journalArticle

Charest-Morin, R, Fisher, CG, Varga, PP, Gokaslan, ZL, Rhines, LD, Reynolds, JJ, Dekutoski, MB, Quraishi, NA, Bilsky, MH, Fehlings, MG, Chou, D, Germscheid, NM, Luzzati, A & Boriani, S 2017, 'En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine', Spine, vol. 42, no. 18, pp. 1383-1390. https://doi.org/10.1097/BRS.0000000000002094
Charest-Morin R, Fisher CG, Varga PP, Gokaslan ZL, Rhines LD, Reynolds JJ et al. En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. Spine. 2017 Jan;42(18):1383-1390. https://doi.org/10.1097/BRS.0000000000002094
Charest-Morin, R ; Fisher, Charles G. ; Varga, Peter Pal ; Gokaslan, Ziya L. ; Rhines, Laurence D. ; Reynolds, Jeremy J. ; Dekutoski, Mark B. ; Quraishi, N. A. ; Bilsky, Mark H. ; Fehlings, Michael G. ; Chou, D ; Germscheid, Niccole M. ; Luzzati, Alessandro ; Boriani, Stefano. / En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. In: Spine. 2017 ; Vol. 42, No. 18. pp. 1383-1390.
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abstract = "STUDY DESIGN Multicenter, ambispective observational study OBJECTIVE.: To quantify local recurrence and mortality rates after surgical treatment of spinal giant cell tumor and to determine whether en bloc resection with wide/marginal margins is associated with improved prognosis compared to an intra-lesional procedure. SUMMARY OF BACKGROUND DATA Giant cell tumor of the spine is a rare primary bone tumor known for its local aggressiveness. Optimal surgical treatment remains to be determined. METHODS The AOSpine Knowledge Forum Tumor developed a comprehensive multicenter database including demographics, presentation, diagnosis, treatment, mortality, and recurrence rate data for giant cell tumor of the spine. Patients were analysed based on surgical margins, including Enneking appropriateness. RESULTS Between 1991 and 2011, 82 patients underwent surgery for spinal giant cell tumor. According to the Enneking classification, 59 (74{\%}) tumors were classified as S3-aggressive and 21 (26{\%}) as S2-active. The surgical margins were wide/ marginal in 27 (36{\%}) patients and intra-lesional in 48 (64{\%}) patients. 39/77 (51{\%}) underwent Enneking appropriate (EA) treatment and 38 (49{\%}) underwent Enneking inappropriate (EI) treatment. Eighteen (22{\%}) patients experienced local recurrence (LR). LR occurred in 11 (29{\%}) EI-treated patients and 6 (15{\%}) EA-treated patients (p = 0.151). There was a significant difference between wide/marginal margins and intra-lesional margins for LR (p = 0.029). Seven (9{\%}) patients died. LR is strongly associated with death (RR 8.9, p < 0.001). Six (16{\%}) EI-treated patients and one (3{\%}) EA-treated patient died (p = 0.056). With regards to surgical margins, all patients who died underwent intra-lesional resection (p = 0.096). CONCLUSION En bloc resection with wide/marginal margins should be performed when technically feasible because it is associated with decreased LR. Intra-lesional resection is associated with increased LR, and mortality correlates with LR.",
author = "R Charest-Morin and Fisher, {Charles G.} and Varga, {Peter Pal} and Gokaslan, {Ziya L.} and Rhines, {Laurence D.} and Reynolds, {Jeremy J.} and Dekutoski, {Mark B.} and Quraishi, {N. A.} and Bilsky, {Mark H.} and Fehlings, {Michael G.} and D Chou and Germscheid, {Niccole M.} and Alessandro Luzzati and Stefano Boriani",
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T1 - En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine

AU - Charest-Morin, R

AU - Fisher, Charles G.

AU - Varga, Peter Pal

AU - Gokaslan, Ziya L.

AU - Rhines, Laurence D.

AU - Reynolds, Jeremy J.

AU - Dekutoski, Mark B.

AU - Quraishi, N. A.

AU - Bilsky, Mark H.

AU - Fehlings, Michael G.

AU - Chou, D

AU - Germscheid, Niccole M.

AU - Luzzati, Alessandro

AU - Boriani, Stefano

PY - 2017/1

Y1 - 2017/1

N2 - STUDY DESIGN Multicenter, ambispective observational study OBJECTIVE.: To quantify local recurrence and mortality rates after surgical treatment of spinal giant cell tumor and to determine whether en bloc resection with wide/marginal margins is associated with improved prognosis compared to an intra-lesional procedure. SUMMARY OF BACKGROUND DATA Giant cell tumor of the spine is a rare primary bone tumor known for its local aggressiveness. Optimal surgical treatment remains to be determined. METHODS The AOSpine Knowledge Forum Tumor developed a comprehensive multicenter database including demographics, presentation, diagnosis, treatment, mortality, and recurrence rate data for giant cell tumor of the spine. Patients were analysed based on surgical margins, including Enneking appropriateness. RESULTS Between 1991 and 2011, 82 patients underwent surgery for spinal giant cell tumor. According to the Enneking classification, 59 (74%) tumors were classified as S3-aggressive and 21 (26%) as S2-active. The surgical margins were wide/ marginal in 27 (36%) patients and intra-lesional in 48 (64%) patients. 39/77 (51%) underwent Enneking appropriate (EA) treatment and 38 (49%) underwent Enneking inappropriate (EI) treatment. Eighteen (22%) patients experienced local recurrence (LR). LR occurred in 11 (29%) EI-treated patients and 6 (15%) EA-treated patients (p = 0.151). There was a significant difference between wide/marginal margins and intra-lesional margins for LR (p = 0.029). Seven (9%) patients died. LR is strongly associated with death (RR 8.9, p < 0.001). Six (16%) EI-treated patients and one (3%) EA-treated patient died (p = 0.056). With regards to surgical margins, all patients who died underwent intra-lesional resection (p = 0.096). CONCLUSION En bloc resection with wide/marginal margins should be performed when technically feasible because it is associated with decreased LR. Intra-lesional resection is associated with increased LR, and mortality correlates with LR.

AB - STUDY DESIGN Multicenter, ambispective observational study OBJECTIVE.: To quantify local recurrence and mortality rates after surgical treatment of spinal giant cell tumor and to determine whether en bloc resection with wide/marginal margins is associated with improved prognosis compared to an intra-lesional procedure. SUMMARY OF BACKGROUND DATA Giant cell tumor of the spine is a rare primary bone tumor known for its local aggressiveness. Optimal surgical treatment remains to be determined. METHODS The AOSpine Knowledge Forum Tumor developed a comprehensive multicenter database including demographics, presentation, diagnosis, treatment, mortality, and recurrence rate data for giant cell tumor of the spine. Patients were analysed based on surgical margins, including Enneking appropriateness. RESULTS Between 1991 and 2011, 82 patients underwent surgery for spinal giant cell tumor. According to the Enneking classification, 59 (74%) tumors were classified as S3-aggressive and 21 (26%) as S2-active. The surgical margins were wide/ marginal in 27 (36%) patients and intra-lesional in 48 (64%) patients. 39/77 (51%) underwent Enneking appropriate (EA) treatment and 38 (49%) underwent Enneking inappropriate (EI) treatment. Eighteen (22%) patients experienced local recurrence (LR). LR occurred in 11 (29%) EI-treated patients and 6 (15%) EA-treated patients (p = 0.151). There was a significant difference between wide/marginal margins and intra-lesional margins for LR (p = 0.029). Seven (9%) patients died. LR is strongly associated with death (RR 8.9, p < 0.001). Six (16%) EI-treated patients and one (3%) EA-treated patient died (p = 0.056). With regards to surgical margins, all patients who died underwent intra-lesional resection (p = 0.096). CONCLUSION En bloc resection with wide/marginal margins should be performed when technically feasible because it is associated with decreased LR. Intra-lesional resection is associated with increased LR, and mortality correlates with LR.

U2 - 10.1097/BRS.0000000000002094

DO - 10.1097/BRS.0000000000002094

M3 - Article

VL - 42

SP - 1383

EP - 1390

JO - Spine

JF - Spine

SN - 0362-2436

IS - 18

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