En bloc resections of bone tumors of the thoracolumbar spine: A preliminary report on 29 patients

Stefano Boriani, Roberto Biagini, Federico De Lure, Franco Bertoni, Maria C. Malaguti, Maria Di Fiore, Antonio Zanoni

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Study Design. Twenty-nine patients with primary bone tumors and solitary metastases of the thoracolumbar spine treated with an bloc resection are reviewed retrospectively. Objective. To demonstrate the possibility to apply in the spine the same principles of surgical oncology adopted for primary bone tumors of the limbs. Summary of Background Data. The surgical oncologic staging systems currently applied in limb tumor surgery are difficult to apply to spinal tumors. The anatomic conditions make extralesional surgery difficult or impossible, which has restrained a more common use of resection surgery in the spine. Focus is put on a new surgical staging system and en bloc vertebral resection. Methods. Twenty-five primary malignant and aggressive benign bone tumors and four solitary metastases were treated. The patients were submitted to oncologic and surgical staging for surgical planning. The primary tumors were classified according to Enneking system: three Stage IA, six Stage IB, eight Stage IIB, eight Stage 3 benign. Staging according to the Weinstein-Boriani-Biagini system was also done. Thirteen lesions involved the vertebral body; nine lesions developed in the posterior arch, or part of it, and seven lesions occupied part of the body and part of the arch. A careful anesthesiologic evaluation was performed as well as a continuous intraoperative on-line monitoring of the vital parameters. The en bloc resections (multi-segmental in five patients) were performed in 10 thoracic, in 16 lumbar, in two thoracolumbar lesions, and in one lumbosacral lesion. Reconstruction was performed, aiming to replace the resected columns. The specimens were submitted to histologic study of the margins. All the patients were followed, and their status was defined on clinical and imaging studies. Results. In 20 patients, a wide margin was achieved, in eight a marginal margin, in one an intralesional margin. The margin was contaminated in seven patients. Surgical time was 3-21 hours (average, 12 hours). No patient died during surgery or from surgical complications. Three mechanical failures of the implants required additional surgery. One deep infection arose. The only neurologic problems observed were related to the nerve roots sectioned for oncologic purpose. No local recurrence was found at follow-up evaluation after 6-134 months (average, 30 months). Conclusions. En bloc resection can be performed in selected tumors of the spine; the indication to such major surgery must be based on the oncologic stage, and the procedure must be carefully planned. For this purpose, the Weinstein-Boriani-Biagini system could be a helpful tool. Long-term results must be weighed before a definitive statement of the indications can be made.

Original languageEnglish
Pages (from-to)1927-1931
Number of pages5
JournalSpine
Volume21
Issue number16
DOIs
Publication statusPublished - Aug 15 1996

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Spine
Bone and Bones
Neoplasms
Extremities
Neoplasm Metastasis
Operative Time
Human Body
Nervous System
Thorax
Recurrence
Infection

Keywords

  • resection
  • spine tumors
  • tumor staging

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Boriani, S., Biagini, R., De Lure, F., Bertoni, F., Malaguti, M. C., Di Fiore, M., & Zanoni, A. (1996). En bloc resections of bone tumors of the thoracolumbar spine: A preliminary report on 29 patients. Spine, 21(16), 1927-1931. https://doi.org/10.1097/00007632-199608150-00020

En bloc resections of bone tumors of the thoracolumbar spine : A preliminary report on 29 patients. / Boriani, Stefano; Biagini, Roberto; De Lure, Federico; Bertoni, Franco; Malaguti, Maria C.; Di Fiore, Maria; Zanoni, Antonio.

In: Spine, Vol. 21, No. 16, 15.08.1996, p. 1927-1931.

Research output: Contribution to journalArticle

Boriani, S, Biagini, R, De Lure, F, Bertoni, F, Malaguti, MC, Di Fiore, M & Zanoni, A 1996, 'En bloc resections of bone tumors of the thoracolumbar spine: A preliminary report on 29 patients', Spine, vol. 21, no. 16, pp. 1927-1931. https://doi.org/10.1097/00007632-199608150-00020
Boriani, Stefano ; Biagini, Roberto ; De Lure, Federico ; Bertoni, Franco ; Malaguti, Maria C. ; Di Fiore, Maria ; Zanoni, Antonio. / En bloc resections of bone tumors of the thoracolumbar spine : A preliminary report on 29 patients. In: Spine. 1996 ; Vol. 21, No. 16. pp. 1927-1931.
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N2 - Study Design. Twenty-nine patients with primary bone tumors and solitary metastases of the thoracolumbar spine treated with an bloc resection are reviewed retrospectively. Objective. To demonstrate the possibility to apply in the spine the same principles of surgical oncology adopted for primary bone tumors of the limbs. Summary of Background Data. The surgical oncologic staging systems currently applied in limb tumor surgery are difficult to apply to spinal tumors. The anatomic conditions make extralesional surgery difficult or impossible, which has restrained a more common use of resection surgery in the spine. Focus is put on a new surgical staging system and en bloc vertebral resection. Methods. Twenty-five primary malignant and aggressive benign bone tumors and four solitary metastases were treated. The patients were submitted to oncologic and surgical staging for surgical planning. The primary tumors were classified according to Enneking system: three Stage IA, six Stage IB, eight Stage IIB, eight Stage 3 benign. Staging according to the Weinstein-Boriani-Biagini system was also done. Thirteen lesions involved the vertebral body; nine lesions developed in the posterior arch, or part of it, and seven lesions occupied part of the body and part of the arch. A careful anesthesiologic evaluation was performed as well as a continuous intraoperative on-line monitoring of the vital parameters. The en bloc resections (multi-segmental in five patients) were performed in 10 thoracic, in 16 lumbar, in two thoracolumbar lesions, and in one lumbosacral lesion. Reconstruction was performed, aiming to replace the resected columns. The specimens were submitted to histologic study of the margins. All the patients were followed, and their status was defined on clinical and imaging studies. Results. In 20 patients, a wide margin was achieved, in eight a marginal margin, in one an intralesional margin. The margin was contaminated in seven patients. Surgical time was 3-21 hours (average, 12 hours). No patient died during surgery or from surgical complications. Three mechanical failures of the implants required additional surgery. One deep infection arose. The only neurologic problems observed were related to the nerve roots sectioned for oncologic purpose. No local recurrence was found at follow-up evaluation after 6-134 months (average, 30 months). Conclusions. En bloc resection can be performed in selected tumors of the spine; the indication to such major surgery must be based on the oncologic stage, and the procedure must be carefully planned. For this purpose, the Weinstein-Boriani-Biagini system could be a helpful tool. Long-term results must be weighed before a definitive statement of the indications can be made.

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