En face optical coherence tomography to detect and measure geographic atrophy

Elisabetta Pilotto, Francesca Guidolin, Enrica Convento, Rachele Antonini, Francesco Giuseppe Stefanon, Raffaele Parrozzani, Edoardo Midena

Research output: Contribution to journalArticlepeer-review


PURPOSE. To detect and quantify geographic atrophy (GA) secondary to age-related macular degeneration using en face optical coherence tomography (OCT) and to correlate it to GA measured with fundus autofluorescence (FAF). METHODS. Twenty-four consecutive patients (27 eyes) were studied with both standard (STD)- and enhanced depth imaging (EDI)-OCT. En face OCT images were obtained at the outer retinal layer (OR) and at the choroidal layer (CH) level for both STD- and EDI-OCT. Areas of GA were measured on the en face OCT images and were correlated with the GA areas measured on blue (B)- and near infrared (NIR)-wavelength FAF images. RESULTS. The intraoperator agreement in GA measurement was excellent with en face OCT at both OR and CH levels (intraclass correlation coefficient [ICC] = 0.99 in EDI and 0.98 in STD at OR level; 0.99 in EDI and 0.99 in STD at CH level). The interoperator agreement was excellent at OR level (ICC = 0.97 in EDI and 0.98 in STD), good at CH level (ICC = 0.95 in EDI, 0.90 in STD). The geographic atrophy area, at both B-FAF and NIR-FAF, was significantly equivalent to the GA area at OR level (B-FAF versus SDT-OR and EDI-OR: P = 0.0057 and 0.0090, respectively; NIR-FAF versus STD-OR and EDI-OR: P = 0.0131 and 0.0036, respectively), but not at CH level. CONCLUSIONS. En face OCT is a reliable method to detect and quantify GA, particularly when analyzed at the OR level, where the photoreceptors’ loss creates an abrupt transition in OCT reflectivity.

Original languageEnglish
Pages (from-to)8120-8124
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Issue number13
Publication statusPublished - Dec 1 2015


  • Age-related macular degeneration
  • En face optical coherence tomography
  • Fundus autofluorescence
  • Geographic atrophy
  • Near infrared fundus autofluorescence

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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