Enalapril decreases plasma prolactin levels in hypertensive patients

C. Lombardi, C. Missale, R. De Cotiis, P. F. Spano

Research output: Contribution to journalArticlepeer-review


Angiotensin II stimulates prolactin release both in vivo in the rat and in vitro in anterior pituitary cell cultures. Moreover, angiotensin II binding sites have been identified in pituitary lactotrophs and it has been shown that angiotensin converting enzyme (ACE) is present in rat anterior pituitary. We studied the effect of enalapril, a potent converting enzyme inhibitor, on baseline prolactin levels in nine hypertensive postmenopausal women. The results indicate that 15-day inhibition of ACE by enalapril reduced prolactinaemia, suggesting that angiotensin II plays a role in the control of prolactin secretion in hypertensives.

Original languageEnglish
Pages (from-to)128-130
Number of pages3
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)


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