Abstract
Angiotensin II stimulates prolactin release both in vivo in the rat and in vitro in anterior pituitary cell cultures. Moreover, angiotensin II binding sites have been identified in pituitary lactotrophs and it has been shown that angiotensin converting enzyme (ACE) is present in rat anterior pituitary. We studied the effect of enalapril, a potent converting enzyme inhibitor, on baseline prolactin levels in nine hypertensive postmenopausal women. The results indicate that 15-day inhibition of ACE by enalapril reduced prolactinaemia, suggesting that angiotensin II plays a role in the control of prolactin secretion in hypertensives.
| Original language | English |
|---|---|
| Pages (from-to) | 128-130 |
| Number of pages | 3 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 3 |
| Issue number | 3 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Physiology (medical)
- Medicine (miscellaneous)
- Physiology
- Agricultural and Biological Sciences(all)
Cite this
Enalapril decreases plasma prolactin levels in hypertensive patients. / Lombardi, C.; Missale, C.; De Cotiis, R.; Spano, P. F.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 3, No. 3, 1989, p. 128-130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enalapril decreases plasma prolactin levels in hypertensive patients
AU - Lombardi, C.
AU - Missale, C.
AU - De Cotiis, R.
AU - Spano, P. F.
PY - 1989
Y1 - 1989
N2 - Angiotensin II stimulates prolactin release both in vivo in the rat and in vitro in anterior pituitary cell cultures. Moreover, angiotensin II binding sites have been identified in pituitary lactotrophs and it has been shown that angiotensin converting enzyme (ACE) is present in rat anterior pituitary. We studied the effect of enalapril, a potent converting enzyme inhibitor, on baseline prolactin levels in nine hypertensive postmenopausal women. The results indicate that 15-day inhibition of ACE by enalapril reduced prolactinaemia, suggesting that angiotensin II plays a role in the control of prolactin secretion in hypertensives.
AB - Angiotensin II stimulates prolactin release both in vivo in the rat and in vitro in anterior pituitary cell cultures. Moreover, angiotensin II binding sites have been identified in pituitary lactotrophs and it has been shown that angiotensin converting enzyme (ACE) is present in rat anterior pituitary. We studied the effect of enalapril, a potent converting enzyme inhibitor, on baseline prolactin levels in nine hypertensive postmenopausal women. The results indicate that 15-day inhibition of ACE by enalapril reduced prolactinaemia, suggesting that angiotensin II plays a role in the control of prolactin secretion in hypertensives.
UR - http://www.scopus.com/inward/record.url?scp=0024833544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024833544&partnerID=8YFLogxK
M3 - Article
C2 - 2560316
AN - SCOPUS:0024833544
VL - 3
SP - 128
EP - 130
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
SN - 0393-974X
IS - 3
ER -