Enalapril decreases plasma prolactin levels in hypertensive patients

C. Lombardi, C. Missale, R. De Cotiis, P. F. Spano

Research output: Contribution to journalArticle

Abstract

Angiotensin II stimulates prolactin release both in vivo in the rat and in vitro in anterior pituitary cell cultures. Moreover, angiotensin II binding sites have been identified in pituitary lactotrophs and it has been shown that angiotensin converting enzyme (ACE) is present in rat anterior pituitary. We studied the effect of enalapril, a potent converting enzyme inhibitor, on baseline prolactin levels in nine hypertensive postmenopausal women. The results indicate that 15-day inhibition of ACE by enalapril reduced prolactinaemia, suggesting that angiotensin II plays a role in the control of prolactin secretion in hypertensives.

Original languageEnglish
Pages (from-to)128-130
Number of pages3
JournalJournal of Biological Regulators and Homeostatic Agents
Volume3
Issue number3
Publication statusPublished - 1989

Fingerprint

Enalapril
angiotensin II
prolactin
Angiotensin II
Prolactin
anterior pituitary
peptidyl-dipeptidase A
Peptidyl-Dipeptidase A
Lactotrophs
enzyme inhibitors
rats
Enzyme Inhibitors
binding sites
cell culture
Cell Culture Techniques
Binding Sites
secretion

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Lombardi, C., Missale, C., De Cotiis, R., & Spano, P. F. (1989). Enalapril decreases plasma prolactin levels in hypertensive patients. Journal of Biological Regulators and Homeostatic Agents, 3(3), 128-130.

Enalapril decreases plasma prolactin levels in hypertensive patients. / Lombardi, C.; Missale, C.; De Cotiis, R.; Spano, P. F.

In: Journal of Biological Regulators and Homeostatic Agents, Vol. 3, No. 3, 1989, p. 128-130.

Research output: Contribution to journalArticle

Lombardi, C, Missale, C, De Cotiis, R & Spano, PF 1989, 'Enalapril decreases plasma prolactin levels in hypertensive patients', Journal of Biological Regulators and Homeostatic Agents, vol. 3, no. 3, pp. 128-130.
Lombardi, C. ; Missale, C. ; De Cotiis, R. ; Spano, P. F. / Enalapril decreases plasma prolactin levels in hypertensive patients. In: Journal of Biological Regulators and Homeostatic Agents. 1989 ; Vol. 3, No. 3. pp. 128-130.
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