Encainide in paroxysmal supraventricular tachycardia: Long term clinical effects

M. Chimienti, M. L. Bergolis, C. Klersy, M. Moizi, J. A. Salerno

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Abstract

The clinical effects and safety of oral encainide were evaluated in 29 patients with paroxysmal supraventricular tachycardia. During a control electrophysiologic study, inducibility and mechanism of tachycardia were determined: 14 patients had atrioventricular (AV) node reentrant tachycardia (AVNRT); 15 had AV reentrant tachycardia (AVRT) involving either a patent (9 patients) or a latent (6 patients) accessory pathway. The mean tachycardia rate was 186 ± 25 beats/min. All patients underwent a repeat electrophysiologic study on treatment with encainide (75-150 mg daily). Tachycardia was reinduced in 8 patients (28%): 7 with AVRT (47%) and only 1 with AVNRT (7%). The tachycardia rate in these patients decreased from 194 ± 21 to 152 ± 26 beats/min (p <0.001). The mean plasma concentrations of encainide and its metabolites O-demethyl-encainide and 3-methoxy-O-demethyl-encainide were 108 ± 219, 167 ± 109, and 120 ± 86 ng/ml, respectively. Three poor metabolizers (10.3%) were found in this series. All patients but one were discharged on encainide at the same dose tested and followed-up for 32 ± 18 months; in 3 patients the dose was subsequently reduced, so the overall mean dose decreased to 114 ± 39 mg daily. Only 3 patients (11%) had less frequent, short-lasting and better tolerated recurrences of tachycardia. The other 25 patients (89%) were totally or almost totally protected by encainide (7 patients with only one short-lasting recurrence). There were only 4 patients complaining of minor side effects: 1 transient hand tremor and 3 mildly blurred vision. In 2 of the latter the symptom disappeared after dose reduction; the last patient refused a dose reduction and was dropped out. We conclude that encainide is extremely effective in preventing paroxysmal supraventricular tachycardia during a prolonged follow-up. When the drug is used at low dosages the incidence of side effects is negligible.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalNew Trends in Arrhythmias
Volume8
Issue number3
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chimienti, M., Bergolis, M. L., Klersy, C., Moizi, M., & Salerno, J. A. (1992). Encainide in paroxysmal supraventricular tachycardia: Long term clinical effects. New Trends in Arrhythmias, 8(3), 537-544.