Encephalopathy with status epilepticus during sleep (ESES) induced by oxcarbazepine in idiopathic focal epilepsy in childhood

Elena Pavlidis, Guido Rubboli, Marina Nikanorova, Margarethe Sophie Kölmel, Elena Gardella

Research output: Contribution to journalArticlepeer-review

Abstract

Encephalopathy with status epilepticus during sleep (ESES) is an age-related disorder characterized by neuropsychological regression, epilepsy and a typical EEG pattern of continuous epileptiform activity (> 85%) during NREM sleep. Cases of worsening or induction of ESES with phenytoin, carbamazepine and phenobarbital have been reported. We describe a child with benign epilepsy with centrotemporal spikes (BECTS) in whom treatment with oxcarbazepine (OXC) induced ESES. The patient was studied through repeated clinical-neuropsychological evaluations and 24-hour EEG recordings. He was treated with OXC two months after epilepsy onset. One month after starting OXC, he developed an abrupt and severe cognitive deterioration. A 24-hour EEG and neuropsychological tests showed an electroclinical picture compatible with ESES. Withdrawal of OXC and introduction of other drugs were followed by a prompt improvement. Five months after ESES onset, a 24-hour EEG was normal. Our report indicates that OXC can induce ESES in BECTS.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalFunctional Neurology
Volume30
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Antiepileptic drugs (AEDs)
  • Benign epilepsy of childhood with centrotemporal spikes (BECTS)
  • Encephalopathy with status epilepticus during sleep (ESES)
  • Idiopathic focal epilepsies of childhood
  • Oxcarbazepine (OXC)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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