Encephalopathy with status epilepticus during slow sleep: "the penelope syndrome"

Carlo A. Tassinari, Gaetano Cantalupo, Loreto Rios-Pohl, Elvio Della Giustina, Guido Rubboli

Research output: Contribution to journalArticlepeer-review


ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
Issue numberSUPPL. 7
Publication statusPublished - Aug 2009


  • Behavioral disturbances
  • Childhood epilepsy
  • Cognitive impairment
  • CSWS
  • ESES
  • Landau-Kleffner syndrome
  • Neuroplasticity
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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