Abstract
ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.
| Original language | English |
|---|---|
| Pages (from-to) | 4-8 |
| Number of pages | 5 |
| Journal | Epilepsia |
| Volume | 50 |
| Issue number | SUPPL. 7 |
| DOIs | |
| Publication status | Published - Aug 2009 |
Fingerprint
Keywords
- Behavioral disturbances
- Childhood epilepsy
- Cognitive impairment
- CSWS
- ESES
- Landau-Kleffner syndrome
- Neuroplasticity
- Sleep
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Encephalopathy with status epilepticus during slow sleep : "the penelope syndrome". / Tassinari, Carlo A.; Cantalupo, Gaetano; Rios-Pohl, Loreto; Giustina, Elvio Della; Rubboli, Guido.
In: Epilepsia, Vol. 50, No. SUPPL. 7, 08.2009, p. 4-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Encephalopathy with status epilepticus during slow sleep
T2 - "the penelope syndrome"
AU - Tassinari, Carlo A.
AU - Cantalupo, Gaetano
AU - Rios-Pohl, Loreto
AU - Giustina, Elvio Della
AU - Rubboli, Guido
PY - 2009/8
Y1 - 2009/8
N2 - ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.
AB - ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.
KW - Behavioral disturbances
KW - Childhood epilepsy
KW - Cognitive impairment
KW - CSWS
KW - ESES
KW - Landau-Kleffner syndrome
KW - Neuroplasticity
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=68149150897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68149150897&partnerID=8YFLogxK
U2 - 10.1111/j.1528-1167.2009.02209.x
DO - 10.1111/j.1528-1167.2009.02209.x
M3 - Article
VL - 50
SP - 4
EP - 8
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - SUPPL. 7
ER -