Encephalopathy with status epilepticus during slow sleep

"the penelope syndrome"

Carlo A. Tassinari, Gaetano Cantalupo, Loreto Rios-Pohl, Elvio Della Giustina, Guido Rubboli

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalEpilepsia
Volume50
Issue numberSUPPL. 7
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Status Epilepticus
Brain Diseases
Sleep
Electroencephalography
Neurobehavioral Manifestations
Neuronal Plasticity
Spouses
Seizures
Learning

Keywords

  • Behavioral disturbances
  • Childhood epilepsy
  • Cognitive impairment
  • CSWS
  • ESES
  • Landau-Kleffner syndrome
  • Neuroplasticity
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Tassinari, C. A., Cantalupo, G., Rios-Pohl, L., Giustina, E. D., & Rubboli, G. (2009). Encephalopathy with status epilepticus during slow sleep: "the penelope syndrome". Epilepsia, 50(SUPPL. 7), 4-8. https://doi.org/10.1111/j.1528-1167.2009.02209.x

Encephalopathy with status epilepticus during slow sleep : "the penelope syndrome". / Tassinari, Carlo A.; Cantalupo, Gaetano; Rios-Pohl, Loreto; Giustina, Elvio Della; Rubboli, Guido.

In: Epilepsia, Vol. 50, No. SUPPL. 7, 08.2009, p. 4-8.

Research output: Contribution to journalArticle

Tassinari, CA, Cantalupo, G, Rios-Pohl, L, Giustina, ED & Rubboli, G 2009, 'Encephalopathy with status epilepticus during slow sleep: "the penelope syndrome"', Epilepsia, vol. 50, no. SUPPL. 7, pp. 4-8. https://doi.org/10.1111/j.1528-1167.2009.02209.x
Tassinari CA, Cantalupo G, Rios-Pohl L, Giustina ED, Rubboli G. Encephalopathy with status epilepticus during slow sleep: "the penelope syndrome". Epilepsia. 2009 Aug;50(SUPPL. 7):4-8. https://doi.org/10.1111/j.1528-1167.2009.02209.x
Tassinari, Carlo A. ; Cantalupo, Gaetano ; Rios-Pohl, Loreto ; Giustina, Elvio Della ; Rubboli, Guido. / Encephalopathy with status epilepticus during slow sleep : "the penelope syndrome". In: Epilepsia. 2009 ; Vol. 50, No. SUPPL. 7. pp. 4-8.
@article{996e910f4541499a80cb9095a1000b5a,
title = "Encephalopathy with status epilepticus during slow sleep: {"}the penelope syndrome{"}",
abstract = "ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.",
keywords = "Behavioral disturbances, Childhood epilepsy, Cognitive impairment, CSWS, ESES, Landau-Kleffner syndrome, Neuroplasticity, Sleep",
author = "Tassinari, {Carlo A.} and Gaetano Cantalupo and Loreto Rios-Pohl and Giustina, {Elvio Della} and Guido Rubboli",
year = "2009",
month = "8",
doi = "10.1111/j.1528-1167.2009.02209.x",
language = "English",
volume = "50",
pages = "4--8",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Blackwell Publishing Inc.",
number = "SUPPL. 7",

}

TY - JOUR

T1 - Encephalopathy with status epilepticus during slow sleep

T2 - "the penelope syndrome"

AU - Tassinari, Carlo A.

AU - Cantalupo, Gaetano

AU - Rios-Pohl, Loreto

AU - Giustina, Elvio Della

AU - Rubboli, Guido

PY - 2009/8

Y1 - 2009/8

N2 - ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.

AB - ESES (encephalopathy with status epilepticus during sleep) is an epileptic encephalopathy with heterogeneous clinical manifestations (cognitive, motor, and behavioral disturbances in different associations, and various seizure types) related to a peculiar electroencephalography (EEG) pattern characterized by paroxysmal activity significantly activated during slow sleep - that is, a condition of continuous spikes and waves, or status epilepticus, during sleep. The pathophysiologic mechanisms underlying this condition are still incompletely understood; recent data suggest that the abnormal epileptic EEG activity occurring during sleep might cause the typical clinical symptoms by interfering with sleep-related physiologic functions, and possibly neuroplasticity processes mediating higher cortical functions such as learning and memory consolidation. As in the myth of Penelope, the wife of Odysseus, what is weaved during the day will be unraveled during the night.

KW - Behavioral disturbances

KW - Childhood epilepsy

KW - Cognitive impairment

KW - CSWS

KW - ESES

KW - Landau-Kleffner syndrome

KW - Neuroplasticity

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=68149150897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149150897&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2009.02209.x

DO - 10.1111/j.1528-1167.2009.02209.x

M3 - Article

VL - 50

SP - 4

EP - 8

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - SUPPL. 7

ER -