End-to-side duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy a comparison trial of small versus larger jejunal incision. A single center experience

F. Francesco Di Mola, Tommaso Grottola, Paolo Panaccio, Francesca Tavano, Antonio De Bonis, Maria Rosa Valvano, Pierluigi Di Sebastiano

Research output: Contribution to journalArticlepeer-review


AIM: The rates of post-operative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) are between 5% and 30%. Nowadays, pancreaticojejunostomy (PJ) represents the most common type of reconstruction after PD, but the ide-al technique is still debated. Our randomized trial was conceived with the intent to evaluate if two variants of PJ could influence the post-opera-tive outcome in term of early complications. MATERIAL AND METHODS: Forty-eight consecutive patients treated with PD were randomized into 2 groups (Group 1 or Large Jejunal Incision or LJI group and Group 2 or Small Jejunal Incision or SJI group). Outcome measures were the operative time, postoperative complications, length of postoperative hospital stay, amylase content in drains. RESULTS: wenty-two patients were enrolled in the LJI and 26 in the SJI group. Median operative times did not differ between the 2 groups. The groups were homogeneous in respect to the median age of patients, the clinical presentation of jaundice and the presence of percutaneous biliary drainage (PBD). POPF developed in 3/22 (13.6%) and 1/26 (4%) patients among the LJI and SJI group respectively (3 grade B and 1 grade C respectively) (p=0.341). PPH occurred in 8/22 (36%) and 2/26 (8%) patients among the LJI and SJI group, respectively (p=0.018). The Amylase content in the drainage fluid measured at the 5th postoperative day showed a higher value in patients who underwent LJI anas-tomosis compared to those with SJI anastomosis [LJI group: 26.5 (6-254) U/l vs SJI group: 7 (0-38) U/l; p=0.051]. Delayed Gastric Emptying (DGE) was not different. The multivariate logistic regression analysis demonstrated both LJI anastomosis and DGE as independent predictors for pancreatic fistula (DGE: OR=20.04, CI 95%=1.92-208.83, P=0.012; LJI anastomosis: OR=24.58, CI 95%=1.71-354.32, P=0.019) and PPH (DGE: 30.5, CI 95%=3.02-308.16, P=0.004; LJI anastomosis: OR=12.71, CI 95%=1.23-131.55, P=0.033). CONCLUSIONS:Based on the present results, we suggest to adopt what a “pancreas duct-oriented” approach: if pancreas duct is large a SJI-PJ is recommended; if the duct is < than 3 mm, a LJI must be preferred. Our conclusion is that the association of some surgeons to perform always the techniques with them are more confident is a concept of the past: recent data suggest that the pancreatic surgeon must have the different techniques in his “armamentarium” and varying the technique depending on local characteristic of the pancreas to allow a tailored approach to the patient.

Original languageEnglish
Pages (from-to)469-477
Number of pages9
JournalAnnali Italiani di Chirurgia
Issue number5
Publication statusPublished - Oct 2020


  • Pancreatic fistula
  • Pancreaticojejunostomy
  • Surgical Sutcome

ASJC Scopus subject areas

  • Surgery


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