Endemic goiter in Calabria: Etiopathogenesis and thyroid function

S. Andò, M. Maggiolini, A. Di Carlo, A. Diodato, A. Bloise, G. P. De Luca, V. Pezzi, D. Sisci, A. Mariano, V. Macchia

Research output: Contribution to journalArticlepeer-review


An endemic goiter study was carried out in a vast territory of the Calabria region, including the provinces of Catanzaro and Cosenza. About 50% of 7231 school-children, aged between 6 and 12 years, examined in 34 villages, presented a thyroid enlargement. The high prevalence of goiter seems to be related to a moderate iodine deficiency intake indicated by a mild urinary iodine excretion (lower than 100 μg/g creatinine). In a few villages, in which a two year voluntary iodine prophylaxis was carried out, an increase in the urinary iodine excretion with a decreased goiter prevalence was observed. A slight increase in TT3, FT3 and TSH in one endemic area studied, compared to the control area, was also observed. These data suggest that an effective program of iodoprophylaxis is fundamental in this region as well.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number5
Publication statusPublished - 1994


  • Endemic goiter
  • free thyroid hormones
  • iodine deficiency
  • iodine excretion
  • thyroglobulin
  • thyrotropic hormone
  • total thyroid hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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