Endobronchial administration of iodine-131 B72.3 monoclonal antibody in patients with lung cancer

Silvana Del Vecchio, Luigi Mansi, Antonella Petrillo, Luigi Camera, Matteo Sofia, Alberto Marra, Luigi Carratú, Marco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

We tested the feasibility of endobronchial administration of radiolabelled monoclonal antibodies (MoAbs) and the biodistribution of the radiotracer. Ten patients with histological confirmed adenocarcinoma or squamous cell carcinoma were studied. Nine received 470 μCi (103 μg) of Iodine-131-B72.3, a monoclonal antibody reacting against TAG 72 antigen, while one patient received 502 μCi (291 μg) of 131I-4C4, an indifferent antibody used for comparison in a negative control study. The radiolabelled antibody was administered through a flexible fiberoptic bronchoscope and placed on the tumour mass under visual monitoring. Scans with a large field-of-view gamma-camera showed retention of 131I-B72.3 at the tumour site up to 6-9 days in six of eight patients. No other organs were visualized with the exception of faint activity in the gastrointestinal tract, bladder and thyroid. On the contrary, the indifferent antibody 131I-4C4 was not retained at the tumour site 6 days after MoAb administration, and more prominent activity was found in the gastrointestinal tract. In one patient the study was not technically adequate because of failure of the delivery system. The vascular compartment contained less than 3% of the administered dose. We conclude that endobronchial administration is a feasible technique and allows stable and specific targetting of bronchial tumours. Furthermore, the low activity found in the plasma and other organs suggests that this approach may be used to deliver therapeutic doses of MoAbs to lung cancers.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalEuropean Journal Of Nuclear Medicine
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 1991

Keywords

  • B72.3
  • Endobronchial administration
  • Lung cancer
  • Monoclonal antibody

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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