Endocannabinoids, hormone-cytokine networks and human fertility

M. Maccarrone, K. Falciglia, M. Di Rienzo, A. Finazzi-Agrò

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Anandamide (N-arachidonoylethanolamine, AEA) is a major endocannabinoid, shown to impair mouse pregnancy and embryo development and to induce apoptosis in blastocysts. Here, we review the roles of AEA, of the AEA-binding cannabinoid (CB) receptors, of the selective AEA membrane transporter (AMT), and of the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), in human gestation. In particular, we discuss the interplay between the endocannabinoid system and the hormone-cytokine array involved in the control of human pregnancy, showing that the endocannabinoids take part in the immunological adaptation occurring during early pregnancy. In this line, we discuss the critical role of FAAH in human peripheral lymphocytes, showing that the expression of this enzyme is regulated by progesterone, Th1 and Th2 cytokines, which also regulate fertility. Moreover, we show that AEA and the other endocannabinoid, 2-arachidonoylglycerol, inhibit the release of the fertility-promoting cytokine leukemia inhibitory factor from human lymphocytes. Taken together, low FAAH and consistently high blood levels of AEA, but not CB receptors or AMT, can be early (

Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume66
Issue number2-3
DOIs
Publication statusPublished - 2002

Fingerprint

Endocannabinoids
Fertility
Hormones
Cytokines
Cannabinoid Receptors
Pregnancy
Membrane Transport Proteins
Lymphocytes
Blastocyst
Enzymes
N-arachidonoylethanolamine
Embryonic Development
Progesterone
Blood
Apoptosis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Endocannabinoids, hormone-cytokine networks and human fertility. / Maccarrone, M.; Falciglia, K.; Di Rienzo, M.; Finazzi-Agrò, A.

In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 66, No. 2-3, 2002, p. 309-317.

Research output: Contribution to journalArticle

Maccarrone, M. ; Falciglia, K. ; Di Rienzo, M. ; Finazzi-Agrò, A. / Endocannabinoids, hormone-cytokine networks and human fertility. In: Prostaglandins, Leukotrienes and Essential Fatty Acids. 2002 ; Vol. 66, No. 2-3. pp. 309-317.
@article{bc4cedb16ee14fcaa3804267fbf19313,
title = "Endocannabinoids, hormone-cytokine networks and human fertility",
abstract = "Anandamide (N-arachidonoylethanolamine, AEA) is a major endocannabinoid, shown to impair mouse pregnancy and embryo development and to induce apoptosis in blastocysts. Here, we review the roles of AEA, of the AEA-binding cannabinoid (CB) receptors, of the selective AEA membrane transporter (AMT), and of the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), in human gestation. In particular, we discuss the interplay between the endocannabinoid system and the hormone-cytokine array involved in the control of human pregnancy, showing that the endocannabinoids take part in the immunological adaptation occurring during early pregnancy. In this line, we discuss the critical role of FAAH in human peripheral lymphocytes, showing that the expression of this enzyme is regulated by progesterone, Th1 and Th2 cytokines, which also regulate fertility. Moreover, we show that AEA and the other endocannabinoid, 2-arachidonoylglycerol, inhibit the release of the fertility-promoting cytokine leukemia inhibitory factor from human lymphocytes. Taken together, low FAAH and consistently high blood levels of AEA, but not CB receptors or AMT, can be early (",
author = "M. Maccarrone and K. Falciglia and {Di Rienzo}, M. and A. Finazzi-Agr{\`o}",
year = "2002",
doi = "10.1054/plef.2001.0354",
language = "English",
volume = "66",
pages = "309--317",
journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",
issn = "0952-3278",
publisher = "Churchill Livingstone",
number = "2-3",

}

TY - JOUR

T1 - Endocannabinoids, hormone-cytokine networks and human fertility

AU - Maccarrone, M.

AU - Falciglia, K.

AU - Di Rienzo, M.

AU - Finazzi-Agrò, A.

PY - 2002

Y1 - 2002

N2 - Anandamide (N-arachidonoylethanolamine, AEA) is a major endocannabinoid, shown to impair mouse pregnancy and embryo development and to induce apoptosis in blastocysts. Here, we review the roles of AEA, of the AEA-binding cannabinoid (CB) receptors, of the selective AEA membrane transporter (AMT), and of the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), in human gestation. In particular, we discuss the interplay between the endocannabinoid system and the hormone-cytokine array involved in the control of human pregnancy, showing that the endocannabinoids take part in the immunological adaptation occurring during early pregnancy. In this line, we discuss the critical role of FAAH in human peripheral lymphocytes, showing that the expression of this enzyme is regulated by progesterone, Th1 and Th2 cytokines, which also regulate fertility. Moreover, we show that AEA and the other endocannabinoid, 2-arachidonoylglycerol, inhibit the release of the fertility-promoting cytokine leukemia inhibitory factor from human lymphocytes. Taken together, low FAAH and consistently high blood levels of AEA, but not CB receptors or AMT, can be early (

AB - Anandamide (N-arachidonoylethanolamine, AEA) is a major endocannabinoid, shown to impair mouse pregnancy and embryo development and to induce apoptosis in blastocysts. Here, we review the roles of AEA, of the AEA-binding cannabinoid (CB) receptors, of the selective AEA membrane transporter (AMT), and of the AEA-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), in human gestation. In particular, we discuss the interplay between the endocannabinoid system and the hormone-cytokine array involved in the control of human pregnancy, showing that the endocannabinoids take part in the immunological adaptation occurring during early pregnancy. In this line, we discuss the critical role of FAAH in human peripheral lymphocytes, showing that the expression of this enzyme is regulated by progesterone, Th1 and Th2 cytokines, which also regulate fertility. Moreover, we show that AEA and the other endocannabinoid, 2-arachidonoylglycerol, inhibit the release of the fertility-promoting cytokine leukemia inhibitory factor from human lymphocytes. Taken together, low FAAH and consistently high blood levels of AEA, but not CB receptors or AMT, can be early (

UR - http://www.scopus.com/inward/record.url?scp=0036019416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036019416&partnerID=8YFLogxK

U2 - 10.1054/plef.2001.0354

DO - 10.1054/plef.2001.0354

M3 - Article

C2 - 12052045

AN - SCOPUS:0036019416

VL - 66

SP - 309

EP - 317

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

SN - 0952-3278

IS - 2-3

ER -