TY - JOUR
T1 - Endocannabinoids in chronic migraine
T2 - CSF findings suggest a system failure
AU - Sarchielli, Paola
AU - Pini, Luigi Alberto
AU - Coppola, Francesca
AU - Rossi, Cristiana
AU - Baldi, Antonio
AU - Mancini, Maria Luisa
AU - Calabresi, Paolo
PY - 2007/6
Y1 - 2007/6
N2 - Based on experimental evidence of the antinociceptive action of endocannabinoids and their role in the modulation of trigeminovascular system activation, we hypothesized that the endocannabinoid system may be dysfunctional in chronic migraine (CM). We examined whether the concentrations of N-arachidonoylethanolamide (anandamide, AEA), palmitoylethanolamide (PEA), and 2-arachidonoylglycerol (2-AG) in the CSF of patients with CM and with probable CM and probable analgesic-overuse headache (PCM+PAOH) are altered compared with control subjects. The above endocannabinoids were measured by high-performance liquid chromatography (HPLC), and quantified by isotope dilution gas-chromatography/mass-spectrometry. Calcitonin gene-related peptide (CGRP) levels were also determined by RIA method and the end products of nitric oxide (NO), the nitrites, by HPLC. CSF concentrations of AEA were significantly lower and those of PEA slightly but significantly higher both in patients with CM and PCM + PAOH than in nonmigraineur controls (p
AB - Based on experimental evidence of the antinociceptive action of endocannabinoids and their role in the modulation of trigeminovascular system activation, we hypothesized that the endocannabinoid system may be dysfunctional in chronic migraine (CM). We examined whether the concentrations of N-arachidonoylethanolamide (anandamide, AEA), palmitoylethanolamide (PEA), and 2-arachidonoylglycerol (2-AG) in the CSF of patients with CM and with probable CM and probable analgesic-overuse headache (PCM+PAOH) are altered compared with control subjects. The above endocannabinoids were measured by high-performance liquid chromatography (HPLC), and quantified by isotope dilution gas-chromatography/mass-spectrometry. Calcitonin gene-related peptide (CGRP) levels were also determined by RIA method and the end products of nitric oxide (NO), the nitrites, by HPLC. CSF concentrations of AEA were significantly lower and those of PEA slightly but significantly higher both in patients with CM and PCM + PAOH than in nonmigraineur controls (p
KW - Analgesic overuse headache
KW - Calcitonin gene-related peptide
KW - Cerebrospinal fluid
KW - Chronic migraine
KW - Endocannabinoids
KW - Nitrites
UR - http://www.scopus.com/inward/record.url?scp=34249100995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249100995&partnerID=8YFLogxK
U2 - 10.1038/sj.npp.1301246
DO - 10.1038/sj.npp.1301246
M3 - Article
C2 - 17119542
AN - SCOPUS:34249100995
VL - 32
SP - 1384
EP - 1390
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
SN - 0893-133X
IS - 6
ER -