Endocannabinoids, related compounds and their metabolic routes

Filomena Fezza, Monica Bari, Rita Florio, Emanuela Talamonti, Monica Feole, Mauro Maccarrone

Research output: Contribution to journalArticlepeer-review


Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Ä9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.

Original languageEnglish
Pages (from-to)17078-17106
Number of pages29
Issue number11
Publication statusPublished - Nov 1 2014


  • 2-arachidonoylglycerol
  • Anandamide
  • Endocannabinoid metabolic routes
  • Fatty acids

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)


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