Endocannabinoids, related compounds and their metabolic routes

Filomena Fezza, Monica Bari, Rita Florio, Emanuela Talamonti, Monica Feole, Mauro Maccarrone

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Ä9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.

Original languageEnglish
Pages (from-to)17078-17106
Number of pages29
JournalMolecules
Volume19
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Endocannabinoids
Lipids
Cannabinoid Receptors
Dronabinol
Bioactivity
Fatty Acids
Pharmacology
Derivatives
Therapeutics

Keywords

  • 2-arachidonoylglycerol
  • Anandamide
  • Endocannabinoid metabolic routes
  • Fatty acids

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Fezza, F., Bari, M., Florio, R., Talamonti, E., Feole, M., & Maccarrone, M. (2014). Endocannabinoids, related compounds and their metabolic routes. Molecules, 19(11), 17078-17106. https://doi.org/10.3390/molecules191117078

Endocannabinoids, related compounds and their metabolic routes. / Fezza, Filomena; Bari, Monica; Florio, Rita; Talamonti, Emanuela; Feole, Monica; Maccarrone, Mauro.

In: Molecules, Vol. 19, No. 11, 01.11.2014, p. 17078-17106.

Research output: Contribution to journalArticle

Fezza, F, Bari, M, Florio, R, Talamonti, E, Feole, M & Maccarrone, M 2014, 'Endocannabinoids, related compounds and their metabolic routes', Molecules, vol. 19, no. 11, pp. 17078-17106. https://doi.org/10.3390/molecules191117078
Fezza, Filomena ; Bari, Monica ; Florio, Rita ; Talamonti, Emanuela ; Feole, Monica ; Maccarrone, Mauro. / Endocannabinoids, related compounds and their metabolic routes. In: Molecules. 2014 ; Vol. 19, No. 11. pp. 17078-17106.
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