Endocrine and bone disease in appropriately treated adult patients with beta-thalassemia major

Marina Baldini, Stella Forti, Alessia Marcon, Fabio Massimo Ulivieri, Alessandra Orsatti, Benedetta Tampieri, Lorena Airaghi, Laura Zanaboni, Maria Domenica Cappellini

Research output: Contribution to journalArticle

Abstract

With the optimization of transfusional and chelation regimens, beta-thalassemia has changed from a pediatric disease with poor life expectancy into a chronic disease. Bone demineralization is an important cause of morbidity in older patients; the etiology is multifactorial and partially unknown. We examined, cross-sectionally, 111 adult patients with beta-thalassemia major (66 females and 45 males, 32.6±6 years) who were regularly transfused, sufficiently chelated and replaced for endocrine defects. Bone demineralization was detected in 92.7% of patients with different severity according to gender and site: osteopenia was the prominent finding at the femur, osteoporosis at the lumbar spine (p

Original languageEnglish
Pages (from-to)1207-1213
Number of pages7
JournalAnnals of Hematology
Volume89
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Endocrinopathy
  • Iron overload
  • Osteoporosis
  • Thalassemia

ASJC Scopus subject areas

  • Hematology

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