Endocrine and clinical results in administering Lisuride for inhibiting lactation

V. L. Zanagnolo, F. Pollini, L. Falsetti, A. Gastaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Lisuride is a potent direct Dopamine agonist and has an effective Prolactin-lowering effect. 64 postpartum women have been divided into two groups: 44 patients with personal reasons to inhibit lactation and 20 patients normally breast-feeding, as a control group. The inhibition of lactation was carried out with Lisuride using 3 x 0.2 mg daily over 10 days, starting within 24-48 hours after delivery. In all the patients we have assayed Prolactin (PRL), LH, FSH and 17-β Estradiol (E2) in basal conditions (1st day after delivery) and on the 5th and 10th day of assumption of the drug. On the 10th day, inhibition of lactation, without symptoms, was obtained in 39 out of 44 patients treated (86.3%). It is clear that, in comparison with the control group, Lusuride leads to a rapid fall of PRL and seems to promote an earlier restoration of the hypothalamus-pituitary-ovary axis, as is shown by the behaviour of gonadotropin and estradiol.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalActa Europaea Fertilitatis
Volume18
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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