Endocrine function in multiple sclerosis: possible correlation with immunitary phenomena

F. Brambilla, C. L. Cazzullo, A. Zibetti, E. Smeraldi

Research output: Contribution to journalArticlepeer-review


The authors studied the endocrine function of 65 patients, 32 females and 33 males, aged 21 to 57 years, with a history of disease of between 1 and 26 years. All the patients had previously received cortisone or ACTH (adrenocorticotrophic hormone) therapy or a combination, but were off treatment at the time of the experiments. Hypothalamo pituitary adrenal function was examined through assay of urinary 17 hydroxycorticosteroids, the ACTH stimulation test and metopirone test. Pituitary function was assessed through GH growth hormone assay on insulin stimulation. Serum immunoglobulin levels were measured as an index of immunity in relation to adrenal function. The results were positive for a normal basal adrenal secretion, with a severe impairment of the ACTH and metopirone tests. The phenomena were present even in the earlier stages of the illness, and more evident in the static than in the dynamic phase. No significant relationship appeared to exist between immunoglobulin levels and endocrine substratum. The significance of the data is discussed.

Original languageEnglish
Pages (from-to)618-625
Number of pages8
JournalActa Neurologica
Issue number6
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Clinical Neurology


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