Endocrine gland derived-VEGF is down-regulated in human pituitary adenoma

Marius Raica, Mihail Coculescu, Anca Maria Cimpean, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review


Background. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic molecule restricted to endocrine glands and, particularly, to steroid-secreting cells. The expression of EG-VEGF and its significance in human adenohypophysis in physiological and pathological conditions is still unknown. Materials and Methods: In this study, we investigated by immunohistochemistry the expression of EG-VEGF in 2 samples of normal adenohypophysis and 43 bioptic samples of pituitary adenoma. Moreover, the expression of growth hormone (GH), prolactin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and adrenocorticoprophic hormone (ACTH) were also estimated. Results: The results of this study for the first time demonstrate a down-regulation of EG-VEGF expression in human pituitary adenoma as compared to normal adenohypophysis, suggesting an impaired function of the neoplastic cells in terms of hormone release in the blood stream, as a consequence of impaired tumor angiogenesis in the tumor. Conclusion: On the basis of our data showing a marked decrease in the expression of EG-VEGF in pituitary adenoma, with the exception of LH-secreting adenomas, we suggest that LH might be involved in the induction of EG-VEGF secretion.

Original languageEnglish
Pages (from-to)3981-3986
Number of pages6
JournalAnticancer Research
Issue number10
Publication statusPublished - Oct 2010


  • Hypophysis
  • Immunohistochemistry
  • Pituitary adenoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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