Abstract
Non-neoplastic proliferative lesions of endocrine cells have been described throughout the gastrointestinal tract and pancreas. A multistep continuum from hyperplasia and dysplasia to neoplasia originally was identified and systematically defined for histamine-producing enterochromaffin-like (ECL) cells of the gastric corpus. More recently, a similar classification system was devised for gastrin (G)- and somatostatin (D)-producing cells in the duodenum. Preneoplastic lesions of the endocrine pancreas still lack a solid and widely accepted definition of a multistep growth process. Similarly, in spite of reports of carcinoid-associated endocrine cell hyperplasia, there is no systematic definition of nonneoplastic lesions of the endocrine cells of the ileum, appendix and colorectum.
| Original language | English |
|---|---|
| Pages (from-to) | 851-865 |
| Number of pages | 15 |
| Journal | Gastroenterology Clinics of North America |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2007 |
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ASJC Scopus subject areas
- Gastroenterology
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Endocrine Hyperplasia and Dysplasia in the Pathogenesis of Gastrointestinal and Pancreatic Endocrine Tumors. / Rindi, Guido; Solcia, Enrico.
In: Gastroenterology Clinics of North America, Vol. 36, No. 4, 12.2007, p. 851-865.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endocrine Hyperplasia and Dysplasia in the Pathogenesis of Gastrointestinal and Pancreatic Endocrine Tumors
AU - Rindi, Guido
AU - Solcia, Enrico
PY - 2007/12
Y1 - 2007/12
N2 - Non-neoplastic proliferative lesions of endocrine cells have been described throughout the gastrointestinal tract and pancreas. A multistep continuum from hyperplasia and dysplasia to neoplasia originally was identified and systematically defined for histamine-producing enterochromaffin-like (ECL) cells of the gastric corpus. More recently, a similar classification system was devised for gastrin (G)- and somatostatin (D)-producing cells in the duodenum. Preneoplastic lesions of the endocrine pancreas still lack a solid and widely accepted definition of a multistep growth process. Similarly, in spite of reports of carcinoid-associated endocrine cell hyperplasia, there is no systematic definition of nonneoplastic lesions of the endocrine cells of the ileum, appendix and colorectum.
AB - Non-neoplastic proliferative lesions of endocrine cells have been described throughout the gastrointestinal tract and pancreas. A multistep continuum from hyperplasia and dysplasia to neoplasia originally was identified and systematically defined for histamine-producing enterochromaffin-like (ECL) cells of the gastric corpus. More recently, a similar classification system was devised for gastrin (G)- and somatostatin (D)-producing cells in the duodenum. Preneoplastic lesions of the endocrine pancreas still lack a solid and widely accepted definition of a multistep growth process. Similarly, in spite of reports of carcinoid-associated endocrine cell hyperplasia, there is no systematic definition of nonneoplastic lesions of the endocrine cells of the ileum, appendix and colorectum.
UR - http://www.scopus.com/inward/record.url?scp=35748954907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35748954907&partnerID=8YFLogxK
U2 - 10.1016/j.gtc.2007.08.006
DO - 10.1016/j.gtc.2007.08.006
M3 - Article
C2 - 17996794
AN - SCOPUS:35748954907
VL - 36
SP - 851
EP - 865
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
SN - 0889-8553
IS - 4
ER -