Endocrine modulation, inhibition of ovarian development and hepatic alterations in rainbow trout exposed to polluted river water

Luigi Vigan, Emilio Benfenati, Sergio Bottero, Alessandra Cevasco, Martino Monteverde, Alberta Mandich

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Under laboratory conditions, female rainbow trout were exposed to graded concentrations of water from the River Lambro, a polluted tributary of the River Po, and to the effluent of a large wastewater treatment plant which flows into the River Lambro. In field exposures, trout were held in cages in the River Po upstream and downstream from the confluence of the River Lambro. After 10-day (laboratory) and 30-day (laboratory and field) exposures, trout were examined for several chemical, biochemical and histological endpoints. The results indicated that exposure to complex mixtures of chemicals, including estrogen receptor agonists, aryl-hydrocarbon receptor agonists, and probably antiandrogens, had occurred. Exposure altered the plasma levels of 17β-estradiol and testosterone, and some treatments also enhanced the activity of hepatic ethoxyresorufin O-deethylase. Gonadal histology showed varying levels of degenerative processes characterised by oocyte atresia, haemorrhages, melano-macrophage centres (MMCs), and oogonia proliferation. Liver histology showed less severe effects.

Original languageEnglish
Pages (from-to)3675-3683
Number of pages9
JournalEnvironmental Pollution
Volume158
Issue number12
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Oncorhynchus mykiss
Rivers
Modulation
Water
Liver
Histology
Trout
Oogonia
Aryl Hydrocarbon Receptors
Androgen Antagonists
Cytochrome P-450 CYP1A1
Macrophages
Waste Water
Complex Mixtures
Wastewater treatment
Oocytes
Testosterone
Effluents
Estradiol
Estrogens

Keywords

  • Antiandrogens
  • Aryl-hydrocarbon receptor agonists
  • Estrogen receptor agonists
  • Oogonia proliferation
  • Ovarian atresia
  • Plasma hormones

ASJC Scopus subject areas

  • Pollution
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Endocrine modulation, inhibition of ovarian development and hepatic alterations in rainbow trout exposed to polluted river water. / Vigan, Luigi; Benfenati, Emilio; Bottero, Sergio; Cevasco, Alessandra; Monteverde, Martino; Mandich, Alberta.

In: Environmental Pollution, Vol. 158, No. 12, 12.2010, p. 3675-3683.

Research output: Contribution to journalArticle

Vigan, Luigi ; Benfenati, Emilio ; Bottero, Sergio ; Cevasco, Alessandra ; Monteverde, Martino ; Mandich, Alberta. / Endocrine modulation, inhibition of ovarian development and hepatic alterations in rainbow trout exposed to polluted river water. In: Environmental Pollution. 2010 ; Vol. 158, No. 12. pp. 3675-3683.
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