Endocrine pattern of the neuroendocrine tumors of the stomach: Clinicopathologic profile and behavior

G. Rindi, D. Paolotti, A. Marchetti, R. Fiocca, E. Solcia

Research output: Contribution to journalArticlepeer-review

Abstract

Gastric endocrine tumors are classified as well differentiated and poorly differentiated. The large majority of well differentiated endocrine tumors are argyrophil enterochromaffin-like (ECL) cell tumors and can be subdivided in Type 1, associated with chronic atrophic gastritis, Type 2 associated with multiple endocrine neoplasia 1 and Zollinger-Ellison syndrome (MEN1-ZES) and Type 3, sporadic, or not associated to specific gastric pathology. Type 1 and 2 tumors are mostly benign in behaviour, while Type 3 tumors are low grade malignant carcinomas. The poorly differentiated endocrine tumors of the stomach are highly malignant and aggressive carcinomas.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalMedecine Biologie Environment
Volume25
Issue number1
Publication statusPublished - 1997

Keywords

  • Argyrophilia
  • Dysplasia
  • ECL cells
  • Electron microscopy
  • Endocrine cells
  • Immunohistochemistry
  • Neoplasia
  • Stomach

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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